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UL11 membrane glycoprotein UL11 [ Human betaherpesvirus 5 ]

Gene ID: 3077560, updated on 18-Aug-2023

Summary

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Gene symbol
UL11
Gene description
membrane glycoprotein UL11
Locus tag
HHV5wtgp017
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human betaherpesvirus 5 (strain: Merlin, acronym: HHV-5; HCMV, nat-host: Homo sapiens, culture-collection: ATCC:VR-1590)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus
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Genomic context

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Sequence:
NC_006273.2 (18642..19460)

NC_006273.2Genomic Context describing neighboring genes Neighboring gene membrane glycoprotein UL9 Neighboring gene membrane protein UL10 Neighboring gene protein UL13 Neighboring gene membrane protein UL14

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_006273.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of the human cytomegalovirus UL11 glycoprotein in viral infection and evaluation of its effect on virus-specific CD8 T cells. Gabaev I, et al. J Virol, 2014 Dec. PMID 25275132, Free PMC Article
  2. The human cytomegalovirus UL11 protein interacts with the receptor tyrosine phosphatase CD45, resulting in functional paralysis of T cells. Gabaev I, et al. PLoS Pathog, 2011 Dec. PMID 22174689, Free PMC Article
  3. The human cytomegalovirus glycoprotein pUL11 acts via CD45 to induce T cell IL-10 secretion. Zischke J, et al. PLoS Pathog, 2017 Jun. PMID 28628650, Free PMC Article
  4. High-resolution human cytomegalovirus transcriptome. Gatherer D, et al. Proc Natl Acad Sci U S A, 2011 Dec 6. PMID 22109557, Free PMC Article
  5. Genetic content of wild-type human cytomegalovirus. Dolan A, et al. J Gen Virol, 2004 May. PMID 15105547

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. pUL11 induces IL-10 producing T cells as a result of pUL11 binding to the CD45 phosphatase on T cells.
    Title: The human cytomegalovirus glycoprotein pUL11 acts via CD45 to induce T cell IL-10 secretion.
  2. These experiments showed that UL11 did not influence the activation of human cytomegalovirus-specific CD8 T cells.
    Title: Expression of the human cytomegalovirus UL11 glycoprotein in viral infection and evaluation of its effect on virus-specific CD8 T cells.
  3. pUL11 has immunosuppressive properties, and that disruption of T cell function via inhibition of CD45 is a previously unknown immunomodulatory strategy of CMV
    Title: The human cytomegalovirus UL11 protein interacts with the receptor tyrosine phosphatase CD45, resulting in functional paralysis of T cells.
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Pathways from PubChem

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General protein information

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Preferred Names
membrane glycoprotein UL11
YP_081471.1
  • RL11 family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_006273.2 Reference assembly

    Range
    18642..19460
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_081471.1 membrane glycoprotein UL11 [Human betaherpesvirus 5]

    See identical proteins and their annotated locations for YP_081471.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    D2K3I1, Q6SWB9
    UniProtKB/TrEMBL
    A0A0U3BAC8, F5HG46, J7EGR8
Nucleotide Protein
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Gene LinkOut

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