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UL97 tegument serine/threonine protein kinase [ Human betaherpesvirus 5 ]

Gene ID: 3077517, updated on 20-Nov-2023
Gene symbol
UL97
Gene description
tegument serine/threonine protein kinase
Locus tag
HHV5wtgp090
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human betaherpesvirus 5 (strain: Merlin, acronym: HHV-5; HCMV, nat-host: Homo sapiens, culture-collection: ATCC:VR-1590)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus
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Sequence:
NC_006273.2 (141798..143921)

NC_006273.2Genomic Context describing neighboring genes Neighboring gene DNA packaging terminase subunit 1 Neighboring gene DNA packaging tegument protein UL17 Neighboring gene tegument protein UL16 Neighboring gene protein UL95 Neighboring gene tegument protein UL14 Neighboring gene deoxyribonuclease Neighboring gene myristylated tegument protein Neighboring gene envelope glycoprotein M

Genomic Sequence:
NC_006273.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Human cytomegalovirus UL97 D605E polymorphism has a high prevalence in immunocompetent Japanese infants and children. Tanaka K, et al. Microbiol Immunol, 2011 May. PMID 21362026
  2. Differential properties of cytomegalovirus pUL97 kinase isoforms affect viral replication and maribavir susceptibility. Webel R, et al. J Virol, 2014 May. PMID 24522923, Free PMC Article
  3. Resistance of human cytomegalovirus to cyclopropavir maps to a base pair deletion in the open reading frame of UL97. Gentry BG, et al. Antimicrob Agents Chemother, 2013 Sep. PMID 23817384, Free PMC Article
  4. Cytomegalovirus UL97 kinase catalytic domain mutations that confer multidrug resistance. Chou S, et al. Antimicrob Agents Chemother, 2013 Jul. PMID 23650173, Free PMC Article
  5. Human cytomegalovirus pUL97 regulates the viral major immediate early promoter by phosphorylation-mediated disruption of histone deacetylase 1 binding. Bigley TM, et al. J Virol, 2013 Jul. PMID 23616659, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Highly Conserved Interaction Profiles between Clinically Relevant Mutants of the Cytomegalovirus CDK-like Kinase pUL97 and Human Cyclins: Functional Significance of Cyclin H.
    Title: Highly Conserved Interaction Profiles between Clinically Relevant Mutants of the Cytomegalovirus CDK-like Kinase pUL97 and Human Cyclins: Functional Significance of Cyclin H.
  2. Prevalence of UL97 gene mutations and polymorphisms in cytomegalovirus infection in the colon associated with or without ulcerative colitis.
    Title: Prevalence of UL97 gene mutations and polymorphisms in cytomegalovirus infection in the colon associated with or without ulcerative colitis.
  3. Cyclins B1, T1, and H differ in their molecular mode of interaction with cytomegalovirus protein kinase pUL97.
    Title: Cyclins B1, T1, and H differ in their molecular mode of interaction with cytomegalovirus protein kinase pUL97.
  4. The pUL97 interaction domain of pp65 was defined (282-415). A putative cyclin bridge that enhances pUL97-pp65 interaction was identified.
    Title: Dynamic regulatory interaction between cytomegalovirus major tegument protein pp65 and protein kinase pUL97 in intracellular compartments, dense bodies and virions.
  5. Mutations detected in this study that led to amino acid substitutions in the IX region of the UL97 gene (A594V, E596K, and S604F) may affect the activity of the pUL97 enzyme, since this region corresponds to the binding site of the phosphotransferase to the viral DNA chain.
    Title: HCMV UL97 phosphotransferase gene mutations may be associated with antiviral resistance in immunocompromised patients in Belém, PA, Northern Brazil.
  6. description of a UL97-polymorphism that contributes to the overall drug-resistance when combined with resistance-associated UL54-mutations
    Title: Identification of resistance-associated HCMV UL97- and UL54-mutations and a UL97-polymporphism with impact on phenotypic drug-resistance.
  7. pUL97 shows differential affinities to human cyclins.
    Title: Proteomic Interaction Patterns between Human Cyclins, the Cyclin-Dependent Kinase Ortholog pUL97 and Additional Cytomegalovirus Proteins.
  8. Rb family proteins are regulated by HCMV UL97 and IE1, which attests to the importance of modulating Rb family protein function in human cytomegalovirus-infected cells
    Title: Human cytomegalovirus-encoded viral cyclin-dependent kinase (v-CDK) UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 and p130 proteins.
  9. The authors conclude that human cytomegalovirus can obtain deoxyribonucleotide triphosphates in the absence of Rb phosphorylation and that viral UL97 can contribute to the efficiency of DNA replication in an Rb phosphorylation-independent manner.
    Title: Human Cytomegalovirus Can Procure Deoxyribonucleotides for Viral DNA Replication in the Absence of Retinoblastoma Protein Phosphorylation.
  10. A significant difference was observed in viral load between seronegative and seropositive of renal transplant recipients. The most frequent mutation was related to D605E in UL97 gene with the rate of 25%. Regardless of viral load, neither putative mutation nor simultaneous mutation was detected in either UL97 and UL54 regions.
    Title: Molecular Analysis of Ganciclovir-Resistant Cytomegalovirus in Renal Transplant Recipients with High Viral Load.
Submit: New GeneRIF Correction See all GeneRIFs (41)
Products Interactant Other Gene Complex Source Pubs Description

Homology

  • core gene
Preferred Names
tegument serine/threonine protein kinase
YP_081544.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_006273.2 Reference assembly

    Range
    141798..143921
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_081544.1 tegument serine/threonine protein kinase [Human betaherpesvirus 5]

    See identical proteins and their annotated locations for YP_081544.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    D2K3Q4, Q6SW46
    UniProtKB/TrEMBL
    A0A1D6WRG5, F5HHG5, Q5IV09
    Conserved Domains (2) summary
    pfam06734
    Location:461 → 642
    UL97; UL97
    cl21453
    Location:337 → 522
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version

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