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Cdh5 cadherin 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307618, updated on 30-Sep-2020

Summary

Official Symbol
Cdh5provided by RGD
Official Full Name
cadherin 5provided by RGD
Primary source
RGD:1307370
See related
Ensembl:ENSRNOG00000013324
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Lung (RPKM 824.9), Heart (RPKM 362.5) and 7 other tissues See more
Orthologs

Genomic context

See Cdh5 in Genome Data Viewer
Location:
19p14
Exon count:
12
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (1025122..1074333, complement)
106 current Rn_Celera (GCF_000002265.2) 19 AC_000087.1 (805477..843688, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 19 NC_005118.3 (1022710..1072784, complement)

Chromosome 19 - NC_005118.4Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S20-like Neighboring gene uncharacterized LOC108348886 Neighboring gene brain expressed, associated with NEDD4, 1 Neighboring gene uncharacterized LOC108348887 Neighboring gene uncharacterized LOC103694277 Neighboring gene uncharacterized LOC108348888

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
BMP receptor binding ISO
Inferred from Sequence Orthology
more info
 
beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fibrinogen binding ISO
Inferred from Sequence Orthology
more info
 
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
vascular endothelial growth factor receptor 2 binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adherens junction organization ISO
Inferred from Sequence Orthology
more info
 
bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
blood vessel maturation ISO
Inferred from Sequence Orthology
more info
 
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
cell-cell adhesion mediated by cadherin ISO
Inferred from Sequence Orthology
more info
 
cell-cell adhesion via plasma-membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell junction assembly ISO
Inferred from Sequence Orthology
more info
 
cellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein localization to bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
regulation of complement-dependent cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
regulation of establishment of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of establishment of cell polarity ISO
Inferred from Sequence Orthology
more info
 
regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
vasculature development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adherens junction ISO
Inferred from Sequence Orthology
more info
 
bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell junction ISO
Inferred from Sequence Orthology
more info
 
cell periphery ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cadherin-5
Names
VE-cadherin
vascular endothelial cadherin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107407.1NP_001100877.1  cadherin-5

    See identical proteins and their annotated locations for NP_001100877.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474006
    Related
    ENSRNOP00000071462.1, ENSRNOT00000086995.1
    Conserved Domains (3) summary
    cd11304
    Location:145244
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:69139
    CA; Cadherin repeats
    pfam01049
    Location:623767
    Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005118.4 Reference Rnor_6.0 Primary Assembly

    Range
    1025122..1074333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000087.1 Alternate Rn_Celera

    Range
    805477..843688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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