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Cdc25c cell division cycle 25C [ Rattus norvegicus (Norway rat) ]

Gene ID: 307511, updated on 4-Jan-2025

Summary

Official Symbol
Cdc25cprovided by RGD
Official Full Name
cell division cycle 25Cprovided by RGD
Primary source
RGD:1311875
See related
EnsemblRapid:ENSRNOG00000024008 AllianceGenome:RGD:1311875
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable WW domain binding activity; protein kinase binding activity; and protein tyrosine phosphatase activity. Involved in spermatogenesis. Located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in endometrial cancer and prostate cancer. Orthologous to human CDC25C (cell division cycle 25C). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 50.8), Spleen (RPKM 37.7) and 9 other tissues See more
Orthologs
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Genomic context

See Cdc25c in Genome Data Viewer
Location:
18p12
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (26608483..26630292, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (26335156..26356199, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (27528768..27550316, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene kinesin family member 20A Neighboring gene cell division cycle 23 Neighboring gene GDNF family receptor alpha 3 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC108348765 Neighboring gene stem-loop binding protein like Neighboring gene family with sequence similarity 53, member C

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables WW domain binding ISO
Inferred from Sequence Orthology
more info
 
enables histone H2AXY142 phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein tyrosine phosphatase activity, metal-dependent IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of G2/MI transition of meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
M-phase inducer phosphatase 3
NP_001388252.1
XP_038952799.1
XP_038952800.1
XP_038952801.1
XP_063133442.1
XP_063133443.1
XP_063133444.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401323.1NP_001388252.1  M-phase inducer phosphatase 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    D4ADT2
    Related
    ENSRNOP00000057498.4, ENSRNOT00000037368.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    26608483..26630292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277373.1XP_063133443.1  M-phase inducer phosphatase 3 isoform X1

    UniProtKB/TrEMBL
    D4ADT2
  2. XM_063277372.1XP_063133442.1  M-phase inducer phosphatase 3 isoform X1

    UniProtKB/TrEMBL
    D4ADT2
  3. XM_063277374.1XP_063133444.1  M-phase inducer phosphatase 3 isoform X2

  4. XM_039096873.2XP_038952801.1  M-phase inducer phosphatase 3 isoform X5

    UniProtKB/TrEMBL
    A6J2V8
    Conserved Domains (1) summary
    cd01530
    Location:89208
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
  5. XM_039096872.2XP_038952800.1  M-phase inducer phosphatase 3 isoform X4

  6. XM_039096871.2XP_038952799.1  M-phase inducer phosphatase 3 isoform X3

RNA

  1. XR_005496040.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107396.1: Suppressed sequence

    Description
    NM_001107396.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.