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bmpr1ba bone morphogenetic protein receptor, type IBa [ Danio rerio (zebrafish) ]

Gene ID: 30742, updated on 9-Sep-2025
Official Symbol
bmpr1baprovided by ZNC
Official Full Name
bone morphogenetic protein receptor, type IBaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-991208-8
See related
Ensembl:ENSDARG00000104100 AllianceGenome:ZFIN:ZDB-GENE-991208-8
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
BR1b; alk6tr; bmpr1b; zALK-6; BMPR-IB; zgc:92220
Summary
Predicted to enable transforming growth factor beta receptor activity, type I. Acts upstream of or within BMP signaling pathway and determination of dorsal identity. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including anterior neural rod; margin; nervous system; optic primordium; and ovarian follicle. Human ortholog(s) of this gene implicated in acromesomelic dysplasia 3; brachydactyly type A1D; brachydactyly type A2; and osteochondrodysplasia. Orthologous to human BMPR1B (bone morphogenetic protein receptor type 1B). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See bmpr1ba in Genome Data Viewer
Location:
chromosome: 5
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 5 NC_133180.1 (8242424..8387254, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 5 NC_007116.7 (7488064..7712160, complement)

Chromosome 5 - NC_133180.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC798124 Neighboring gene sperm-tail PG-rich repeat containing 2 Neighboring gene unc-5 netrin receptor Ca Neighboring gene U6 spliceosomal RNA Neighboring gene PDZ and LIM domain 5a Neighboring gene opsin 4xb

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Integration of Hedgehog and BMP signalling by the engrailed2a gene in the zebrafish myotome. Maurya AK, et al. Development, 2011 Feb. PMID 21266411
  2. Reduced GS Domain Serine/Threonine Requirements of Fibrodysplasia Ossificans Progressiva Mutant Type I BMP Receptor ACVR1 in the Zebrafish. Allen RS, et al. J Bone Miner Res, 2023 Sep. PMID 37329499, Free PMC Article
  3. BMP2 Is Related to Hirschsprung's Disease and Required for Enteric Nervous System Development. Huang S, et al. Front Cell Neurosci, 2019. PMID 31849612, Free PMC Article
  4. Blood flow and Bmp signaling control endocardial chamber morphogenesis. Dietrich AC, et al. Dev Cell, 2014 Aug 25. PMID 25158852
  5. BMP regulation of myogenesis in zebrafish. Patterson SE, et al. Dev Dyn, 2010 Mar. PMID 20151472, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Clone Names

  • MGC92220

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transforming growth factor beta receptor activity, type I IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane receptor protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within determination of dorsal identity IMP
Inferred from Mutant Phenotype
more info
  
involved_in dorsal/ventral pattern formation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
bone morphogenetic protein receptor type-1B
Names
alk6
bone morphogenetic protein receptor, type 1b
bone morphogenetic protein receptor, type 1ba
NP_571532.1
XP_021331677.2
XP_073805896.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131457.2 → NP_571532.1  bone morphogenetic protein receptor type-1B precursor

    See identical proteins and their annotated locations for NP_571532.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081625
    UniProtKB/TrEMBL
    A0A8M9PJN6, Q66HY2, Q9W629
    Related
    ENSDARP00000140548.1, ENSDART00000168820.2
    Conserved Domains (3) summary
    smart00220
    Location:233 → 517
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14219
    Location:226 → 530
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:61 → 138
    Activin_recp; Activin types I and II receptor domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133180.1 Reference GRCz12tu Primary Assembly

    Range
    8242424..8387254 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476002.3 → XP_021331677.2  bone morphogenetic protein receptor type-1B isoform X1

    UniProtKB/TrEMBL
    A0A8M9PJN6, Q66HY2, Q9W629

  2. XM_073949795.1 → XP_073805896.1  bone morphogenetic protein receptor type-1B isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.