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elavl1a ELAV like RNA binding protein 1a [ Danio rerio (zebrafish) ]

Gene ID: 30736, updated on 9-Sep-2025
Official Symbol
elavl1aprovided by ZNC
Official Full Name
ELAV like RNA binding protein 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-245
See related
Ensembl:ENSDARG00000038695 AllianceGenome:ZFIN:ZDB-GENE-990415-245
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hua; elra; zHuA; elavl1; fa25f08; fb59a02; fc60g02; wu:fa25f08; wu:fb59a02; wu:fc60g02
Summary
Enables single-stranded RNA binding activity. Acts upstream of with a positive effect on RNA stabilization. Acts upstream of or within erythrocyte differentiation and positive regulation of angiogenesis. Predicted to be located in cytoplasm and nucleus. Predicted to be part of ribonucleoprotein complex. Is expressed in oocyte and skeletal muscle. Orthologous to human ELAVL1 (ELAV like RNA binding protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See elavl1a in Genome Data Viewer
Location:
chromosome: 2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 2 NC_133177.1 (40102774..40113628, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 2 NC_007113.7 (37123338..37134191, complement)

Chromosome 2 - NC_133177.1Genomic Context describing neighboring genes Neighboring gene zgc:101744 Neighboring gene solute carrier family 1 member 8b Neighboring gene peroxisomal biogenesis factor 19 Neighboring gene tetraspanin 37 Neighboring gene uncharacterized LOC141378477

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. ELAVL1 promotes LPS-induced endothelial cells injury through modulation of cytokine storm. Zhou C, et al. Immunobiology, 2023 Jul. PMID 37343439
  2. ELAVL1a is an immunocompetent protein that protects zebrafish embryos from bacterial infection. Ni S, et al. Commun Biol, 2021 Feb 26. PMID 33637956, Free PMC Article
  3. Phosphorylation of ELAVL1 (Ser219/Ser316) mediated by PKC is required for erythropoiesis. Zhou X, et al. Biochim Biophys Acta Mol Cell Res, 2019 Feb. PMID 30395882
  4. The metalloproteinase inhibitor Reck is essential for zebrafish DRG development. Prendergast A, et al. Development, 2012 Mar. PMID 22296847, Free PMC Article
  5. The expression of CPEB proteins is sequentially regulated during zebrafish oogenesis and embryogenesis. O'Connell ML, et al. Mol Reprod Dev, 2014 Apr. PMID 24474627

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ELAVL1 promotes LPS-induced endothelial cells injury through modulation of cytokine storm.
    Title: ELAVL1 promotes LPS-induced endothelial cells injury through modulation of cytokine storm.
  2. ELAVL1a is an immunocompetent protein that protects zebrafish embryos from bacterial infection.
    Title: ELAVL1a is an immunocompetent protein that protects zebrafish embryos from bacterial infection.
  3. this study reveals a posttranscriptional regulatory mechanism by which RNA-binding protein Elavl1a regulates embryonic erythropoiesis by maintaining appropriate levels of gata1 expression.
    Title: Elavl1a regulates zebrafish erythropoiesis via posttranscriptional control of gata1.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
ELAV-like protein 1a
Names
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
ELAV like RNA binding protein 1
elav-related A
embryonic lethal, abnormal vision-related A
etID309757.2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131452.1 → NP_571527.1  ELAV-like protein 1a

    See identical proteins and their annotated locations for NP_571527.1

    Status: PROVISIONAL

    Source sequence(s)
    AF184244
    UniProtKB/TrEMBL
    Q9PTK5
    Related
    ENSDARP00000040426.5, ENSDART00000040427.6
    Conserved Domains (4) summary
    cd12650
    Location:17 → 94
    RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
    cd12773
    Location:104 → 187
    RRM2_HuR; RNA recognition motif 2 in vertebrate Hu-antigen R (HuR)
    TIGR01661
    Location:15 → 324
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl17169
    Location:241 → 324
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133177.1 Reference GRCz12tu Primary Assembly

    Range
    40102774..40113628 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068222966.1 → XP_068079067.1  ELAV-like protein 1a isoform X2

    UniProtKB/TrEMBL
    A0A8M3AQB0

  2. XM_009298634.2 → XP_009296909.1  ELAV-like protein 1a isoform X2

    UniProtKB/TrEMBL
    A0A8M3AQB0
    Conserved Domains (1) summary
    cl17169
    Location:127 → 210
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. XM_005171267.5 → XP_005171324.1  ELAV-like protein 1a isoform X1

    See identical proteins and their annotated locations for XP_005171324.1

    UniProtKB/TrEMBL
    A0A8M2BIL8, F1QM02
    Related
    ENSDARP00000120506.1, ENSDART00000146123.3
    Conserved Domains (4) summary
    cd12650
    Location:33 → 110
    RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
    cd12653
    Location:257 → 340
    RRM3_HuR; RNA recognition motif 3 in vertebrate Hu-antigen R (HuR)
    cd12773
    Location:120 → 203
    RRM2_HuR; RNA recognition motif 2 in vertebrate Hu-antigen R (HuR)
    TIGR01661
    Location:31 → 340
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  4. XM_073912074.1 → XP_073768175.1  ELAV-like protein 1a isoform X2

    UniProtKB/TrEMBL
    A0A8M3AQB0

  5. XM_017357655.2 → XP_017213144.1  ELAV-like protein 1a isoform X1

    UniProtKB/TrEMBL
    A0A8M2BIL8, F1QM02
    Conserved Domains (4) summary
    cd12650
    Location:33 → 110
    RRM1_Hu; RNA recognition motif 1 in the Hu proteins family
    cd12653
    Location:257 → 340
    RRM3_HuR; RNA recognition motif 3 in vertebrate Hu-antigen R (HuR)
    cd12773
    Location:120 → 203
    RRM2_HuR; RNA recognition motif 2 in vertebrate Hu-antigen R (HuR)
    TIGR01661
    Location:31 → 340
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  6. XM_073912078.1 → XP_073768179.1  ELAV-like protein 1a isoform X2

    UniProtKB/TrEMBL
    A0A8M3AQB0

  7. XM_073912056.1 → XP_073768157.1  ELAV-like protein 1a isoform X1

    UniProtKB/TrEMBL
    A0A8M2BIL8, F1QM02
Nucleotide Protein Strain
Heading Accession and Version

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