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Afg3l2 AFG3 like matrix AAA peptidase subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307350, updated on 2-Oct-2018

Summary

Official Symbol
Afg3l2provided by RGD
Official Full Name
AFG3 like matrix AAA peptidase subunit 2provided by RGD
Primary source
RGD:1305259
See related
Ensembl:ENSRNOG00000017965
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Heart (RPKM 328.8), Adrenal (RPKM 223.9) and 9 other tissues See more
Orthologs

Genomic context

See Afg3l2 in Genome Data Viewer
Location:
18q12.1
Exon count:
17
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (63141418..63185510, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 18 NC_005117.3 (62325697..62369789, complement)

Chromosome 18 - NC_005117.4Genomic Context describing neighboring genes Neighboring gene cell death-inducing DFFA-like effector a Neighboring gene tubulin, beta 6 class V Neighboring gene cytochrome b-c1 complex subunit 7 pseudogene Neighboring gene PRELI domain containing 3A Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Homology

Clone Names

  • MGC109579

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
molecular_function ND
No biological Data available
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
axonogenesis IEA
Inferred from Electronic Annotation
more info
 
axonogenesis ISO
Inferred from Sequence Orthology
more info
 
biological_process ND
No biological Data available
more info
 
calcium import into the mitochondrion IEA
Inferred from Electronic Annotation
more info
 
calcium import into the mitochondrion ISO
Inferred from Sequence Orthology
more info
 
cristae formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cristae formation ISO
Inferred from Sequence Orthology
more info
 
mitochondrial calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
mitochondrial calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
mitochondrial fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial fusion ISO
Inferred from Sequence Orthology
more info
 
mitochondrial protein processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial protein processing ISO
Inferred from Sequence Orthology
more info
 
mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
muscle fiber development IEA
Inferred from Electronic Annotation
more info
 
muscle fiber development ISO
Inferred from Sequence Orthology
more info
 
myelination IEA
Inferred from Electronic Annotation
more info
 
myelination ISO
Inferred from Sequence Orthology
more info
 
nerve development IEA
Inferred from Electronic Annotation
more info
 
nerve development ISO
Inferred from Sequence Orthology
more info
 
neuromuscular junction development IEA
Inferred from Electronic Annotation
more info
 
neuromuscular junction development ISO
Inferred from Sequence Orthology
more info
 
protein autoprocessing IEA
Inferred from Electronic Annotation
more info
 
protein autoprocessing ISO
Inferred from Sequence Orthology
more info
 
protein processing ISO
Inferred from Sequence Orthology
more info
 
proteolysis ISO
Inferred from Sequence Orthology
more info
 
regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
righting reflex IEA
Inferred from Electronic Annotation
more info
 
righting reflex ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
m-AAA complex IEA
Inferred from Electronic Annotation
more info
 
m-AAA complex ISO
Inferred from Sequence Orthology
more info
 
mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
AFG3-like protein 2
Names
AFG3 ATPase family member 3-like 2
AFG3-like AAA ATPase 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134864.1NP_001128336.1  AFG3-like protein 2

    Status: PROVISIONAL

    Source sequence(s)
    AABR07032372
    UniProtKB/TrEMBL
    F1LN92
    Related
    ENSRNOP00000024632.4, ENSRNOT00000024632.5
    Conserved Domains (4) summary
    TIGR01241
    Location:252745
    FtsH_fam; ATP-dependent metalloprotease FtsH
    pfam00004
    Location:344475
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam01434
    Location:561743
    Peptidase_M41; Peptidase family M41
    pfam06480
    Location:145241
    FtsH_ext; FtsH Extracellular

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005117.4 Reference Rnor_6.0 Primary Assembly

    Range
    63141418..63185510 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000086.1 Alternate Rn_Celera

    Range
    59060862..59105674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013140.1: Suppressed sequence

    Description
    NM_001013140.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
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