Arhgap21 Rho GTPase activating protein 21 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arhgap21provided by RGD
Official Full Name: Rho GTPase activating protein 21provided by RGD
Primary source: RGD:1311028
See related: Ensembl:ENSRNOG00000008659 AllianceGenome:RGD:1311028
Gene type: protein coding
RefSeq status: INFERRED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in several processes, including establishment of Golgi localization; maintenance of Golgi location; and organelle transport along microtubule. Predicted to act upstream of or within regulation of endocytosis. Predicted to be located in several cellular components, including Golgi apparatus; actin cytoskeleton; and cell junction. Orthologous to human ARHGAP21 (Rho GTPase activating protein 21). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Heart (RPKM 339.6), Brain (RPKM 205.6) and 9 other tissues See more
Orthologs: all
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Genomic context

Location:: 17q12.3

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (88256961..88380478, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (83348673..83472202, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (87725978..87797436, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that ARHGAP21 may act as a signaling or scaffold protein of FAK and PKCzeta signaling pathways, developing an important function during cardiac stress.
Title: ARHGAP21 associates with FAK and PKCzeta and is redistributed after cardiac pressure overload.

Submit: New GeneRIF Correction

General gene information

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Markers

RH142975 (e-PCR)
- UniSTS:232222

RH144578 (e-PCR)
- UniSTS:233823

D17Got104 (e-PCR)
- UniSTS:113372

RH134054 (e-PCR)
- UniSTS:217336

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Golgi localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi organization	IEA Inferred from Electronic Annotation more info
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in establishment of Golgi localization	IEA Inferred from Electronic Annotation more info
involved_in establishment of Golgi localization	ISO Inferred from Sequence Orthology more info
involved_in maintenance of Golgi location	IEA Inferred from Electronic Annotation more info
involved_in maintenance of Golgi location	ISO Inferred from Sequence Orthology more info
involved_in organelle transport along microtubule	IEA Inferred from Electronic Annotation more info
involved_in organelle transport along microtubule	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho GTPase-activating protein 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191693.1 → NP_001178622.1 rho GTPase-activating protein 21

Status: INFERRED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A0A8I5ZNY8

Related

ENSRNOP00000078699.2, ENSRNOT00000096893.2

Conserved Domains (4) summary

cd00992
Location:52 → 159

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04395
Location:1147 → 1342

RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...

cd01253
Location:936 → 1045

PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

pfam00169
Location:937 → 1042

PH; PH domain