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Apbb1ip amyloid beta precursor protein binding family B member 1 interacting protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 307171, updated on 13-Apr-2024

Summary

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Official Symbol
Apbb1ipprovided by RGD
Official Full Name
amyloid beta precursor protein binding family B member 1 interacting proteinprovided by RGD
Primary source
RGD:1304795
See related
Ensembl:ENSRNOG00000017803 AllianceGenome:RGD:1304795
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in signal transduction. Predicted to act upstream of or within T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell and positive regulation of cell adhesion. Predicted to be part of T cell receptor complex. Predicted to be active in cytosol and plasma membrane. Orthologous to human APBB1IP (amyloid beta precursor protein binding family B member 1 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 116.4), Spleen (RPKM 107.2) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
17q12.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (89849474..89941099)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (84941404..85033020)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (90098953..90149192, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene glutamate decarboxylase 2 Neighboring gene uncharacterized LOC134482619 Neighboring gene decaprenyl diphosphate synthase subunit 1 Neighboring gene abl-interactor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of T cell receptor complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Names
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100577.1 → NP_001094047.1  amyloid beta A4 precursor protein-binding family B member 1-interacting protein

    See identical proteins and their annotated locations for NP_001094047.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A6KS00, D3ZDZ1
    Related
    ENSRNOP00000024272.6, ENSRNOT00000024272.7
    Conserved Domains (2) summary
    cd01259
    Location:308 → 429
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16137
    Location:185 → 266
    RA_MRL_RIAM; Ras-associating (RA) domain found in Rap1-GTP-interacting adapter molecule (RIAM)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    89849474..89941099
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095818.2 → XP_038951746.1  amyloid beta A4 precursor protein-binding family B member 1-interacting protein isoform X1

    UniProtKB/TrEMBL
    A6KS00, D3ZDZ1
    Conserved Domains (2) summary
    cd01259
    Location:308 → 429
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16137
    Location:185 → 266
    RA_MRL_RIAM; Ras-associating (RA) domain found in Rap1-GTP-interacting adapter molecule (RIAM)

  2. XM_039095819.2 → XP_038951747.1  amyloid beta A4 precursor protein-binding family B member 1-interacting protein isoform X2

    Conserved Domains (2) summary
    cd01259
    Location:156 → 277
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16137
    Location:33 → 114
    RA_MRL_RIAM; Ras-associating (RA) domain found in Rap1-GTP-interacting adapter molecule (RIAM)
Nucleotide Protein Strain
Heading Accession and Version

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