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raf1a Raf-1 proto-oncogene, serine/threonine kinase a [ Danio rerio (zebrafish) ]

Gene ID: 30716, updated on 11-Apr-2024

Summary

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Official Symbol
raf1aprovided by ZNC
Official Full Name
Raf-1 proto-oncogene, serine/threonine kinase aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-41
See related
Ensembl:ENSDARG00000096415 AllianceGenome:ZFIN:ZDB-GENE-990415-41
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
craf; raf1; c-raf
Summary
Predicted to enable MAP kinase kinase kinase activity. Acts upstream of or within heart development and regulation of MAPK cascade. Predicted to be active in cytosol; mitochondrion; and plasma membrane. Is expressed in blastoderm; blastomere; and head. Human ortholog(s) of this gene implicated in Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 2; adenocarcinoma (multiple); and dilated cardiomyopathy 1NN. Orthologous to human RAF1 (Raf-1 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: suggests misassembly
Orthologs
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Genomic context

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Location:
chromosome: 23
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (4709750..4747277)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (4773877..4811692)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene glycoprotein IX platelet Neighboring gene CCHC-type zinc finger, nucleic acid binding protein a Neighboring gene synapsin IIa Neighboring gene vestigial-like family member 4a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. ARAF recurrent mutation causes central conducting lymphatic anomaly treatable with a MEK inhibitor. Li D, et al. Nat Med, 2019 Jul. PMID 31263281
  2. Disrupting Rb-Raf-1 interaction inhibits hair cell regeneration in zebrafish lateral line neuromasts. Lin Q, et al. Neuroreport, 2013 Mar 6. PMID 23381351
  3. Functional analysis of a phosphatidic acid binding domain in human Raf-1 kinase: mutations in the phosphatidate binding domain lead to tail and trunk abnormalities in developing zebrafish embryos. Ghosh S, et al. J Biol Chem, 2003 Nov 14. PMID 12925535
  4. Germline gain-of-function mutations in RAF1 cause Noonan syndrome. Razzaque MA, et al. Nat Genet, 2007 Aug. PMID 17603482
  5. RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome. Bögershausen N, et al. J Clin Invest, 2015 Sep. PMID 26280580, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. cdk10 has roles in vertebrate development and a critical function in neurogenesis by modulation of raf1a expression
    Title: Knockdown of cyclin-dependent kinase 10 (cdk10) gene impairs neural progenitor survival via modulation of raf1a gene expression.
  2. Our results indicate that Rb-Raf-1 interaction plays an important role in spontaneous hair cell regeneration in zebrafish
    Title: Disrupting Rb-Raf-1 interaction inhibits hair cell regeneration in zebrafish lateral line neuromasts.
  3. analysis of the roles of Raf- and PI3K-signalling pathways in melanoma
    Title: Dissecting the roles of Raf- and PI3K-signalling pathways in melanoma formation and progression in a zebrafish model.
  4. Zebrafish embryos with morpholino knockdown of raf1 demonstrated the need for raf1 for the development of normal myocardial structure and function.
    Title: Germline gain-of-function mutations in RAF1 cause Noonan syndrome.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of MAPK cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RAF proto-oncogene serine/threonine-protein kinase; Raf-1 proto-oncogene, serine/threonine kinase a
Names
murine leukemia viral oncogene homolog
serine/threonine protein kinase RAF1
v-raf-1 murine leukemia viral oncogene homolog 1
v-raf-1 murine leukemia viral oncogene homolog 1a
NP_571514.2
XP_017208994.1
XP_017208996.1
XP_021325405.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131439.2 → NP_571514.2  Raf-1 proto-oncogene, serine/threonine kinase a

    Status: VALIDATED

    Source sequence(s)
    CABZ01046288, CABZ01066947, CU468010, CU571070, FO818741
    UniProtKB/TrEMBL
    A0A0R4IN14, A0A8M1P820
    Related
    ENSDARP00000137636.2, ENSDART00000163860.2
    Conserved Domains (4) summary
    cd01816
    Location:50 → 124
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14149
    Location:332 → 614
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    pfam00069
    Location:346 → 601
    Pkinase; Protein kinase domain
    pfam00130
    Location:132 → 180
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    4709750..4747277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017353505.1 → XP_017208994.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

    UniProtKB/TrEMBL
    D3KYU7
    Conserved Domains (4) summary
    cd01816
    Location:50 → 124
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14149
    Location:315 → 597
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    pfam00069
    Location:329 → 584
    Pkinase; Protein kinase domain
    pfam00130
    Location:132 → 180
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  2. XM_021469730.1 → XP_021325405.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A8M9PWA5
    Conserved Domains (3) summary
    cd01816
    Location:50 → 124
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14149
    Location:317 → 599
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    pfam00130
    Location:132 → 180
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  3. XM_017353507.1 → XP_017208996.1  RAF proto-oncogene serine/threonine-protein kinase isoform X3

    UniProtKB/TrEMBL
    A0A8M6Z3N3
    Related
    ENSDARP00000130779.2, ENSDART00000166503.2
Nucleotide Protein Strain
Heading Accession and Version

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