fabp2 fatty acid binding protein 2, intestinal [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fabp2provided by ZNC
Official Full Name: fatty acid binding protein 2, intestinalprovided by ZNC
Primary source: ZFIN:ZDB-GENE-991019-5
See related: Ensembl:ENSDARG00000006427 AllianceGenome:ZFIN:ZDB-GENE-991019-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ifabp; I-FABP; zgc:92264
Summary: Predicted to enable long-chain fatty acid binding activity. Acts upstream of or within response to lipid. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in brain; digestive system; and kidney. Human ortholog(s) of this gene implicated in alcoholic liver cirrhosis; carotid stenosis; coronary artery disease; end stage renal disease; and obesity. Orthologous to human FABP2 (fatty acid binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (25848236..25851530)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (25157402..25160701)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intestinal fatty acid binding protein (I-FABP) and CXC3L1 evaluation as biomarkers for patients at high-risk for coeliac disease in Johannesburg, South Africa.
Title: Intestinal fatty acid binding protein (I-FABP) and CXC3L1 evaluation as biomarkers for patients at high-risk for coeliac disease in Johannesburg, South Africa.
n-3 PUFA reduction caused by fabp2 deletion interferes with triacylglycerol metabolism and cholesterolhomeostasis in fish.
Title: n-3 PUFA reduction caused by fabp2 deletion interferes with triacylglycerol metabolism and cholesterolhomeostasis in fish.
In vivo experiments demonstrated, for the first time, that intestinal absorption of dietary BODIPY-FLC(12) was followed by colocalization of the labeled FA with Fabp1b and Fabp2 in the nuclei.
Title: Fatty acid binding proteins have the potential to channel dietary fatty acids into enterocyte nuclei.
transcription of single copy fabp2 is modulated by dietary fatty acids and clofibrate in a tissue specific fashion.
Title: Tissue-specific transcriptional modulation of fatty acid-binding protein genes, fabp2, fabp3 and fabp6, by fatty acids and the peroxisome proliferator, clofibrate, in zebrafish (Danio rerio).
Ifabp mRNAs were initially expressed in the zebrafish yolk syncytial layer at the ventral side during late epiboly (8-9 hpf), spread throughout the YSL of later stage embryos, and appeared in the intestine rudiment at approximately 36 hpf
Title: Expression analyses of zebrafish transferrin, ifabp, and elastaseB mRNAs as differentiation markers for the three major endodermal organs: liver, intestine, and exocrine pancreas.
analysis of conserved elements that mediate intestinal-type fatty acid binding protein (I-FABP) expression in the gut epithelia of zebrafish larvae
Title: Functional conserved elements mediate intestinal-type fatty acid binding protein (I-FABP) expression in the gut epithelia of zebrafish larvae.
dna analysis, linkage mapping and early developmental expression of the intestinal-type fatty acid-binding protein gene (fabp2) from zebrafish
Title: Sequence, linkage mapping and early developmental expression of the intestinal-type fatty acid-binding protein gene (fabp2) from zebrafish (Danio rerio).

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to lipid	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within triglyceride homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fatty acid-binding protein, intestinal

Names: I-FABP (FABPI); intestinal fatty acid binding pr; intestinal fatty acid binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131431.1 → NP_571506.1 fatty acid-binding protein, intestinal

See identical proteins and their annotated locations for NP_571506.1

Status: PROVISIONAL

Source sequence(s)

AF541953

UniProtKB/TrEMBL

Q8AX65

Related

ENSDARP00000021241.4, ENSDART00000027973.6

Conserved Domains (1) summary

pfam00061
Location:4 → 132

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007112.7 Reference GRCz11 Primary Assembly

Range

25848236..25851530

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005170903.3 → XP_005170960.1 fatty acid-binding protein, intestinal isoform X1

UniProtKB/TrEMBL

A0A8M2BI88

Conserved Domains (1) summary

pfam00061
Location:4 → 114

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family