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lef1 lymphoid enhancer-binding factor 1 [ Danio rerio (zebrafish) ]

Gene ID: 30701, updated on 22-Nov-2020

Summary

Official Symbol
lef1provided by ZNC
Official Full Name
lymphoid enhancer-binding factor 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-990714-26
See related
Ensembl:ENSDARG00000031894
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Annotation information
Annotation category: partial on reference assembly
Orthologs

Genomic context

See lef1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (49814548..49903487)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (49170722..49259661)
103 previous assembly Zv9 (GCF_000002035.4) 1 NC_007112.5 (50321631..50410570)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene testis specific, 10 Neighboring gene cracd like b Neighboring gene hydroxyacyl-CoA dehydrogenase Neighboring gene cytochrome P450, family 2, subfamily U, polypeptide 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding, bending ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
beta-catenin binding IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
caudal fin development IMP
Inferred from Mutant Phenotype
more info
PubMed 
fin development IMP
Inferred from Mutant Phenotype
more info
PubMed 
fin morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
fin regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
forebrain neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
hypothalamus cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
hypothalamus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
muscle fiber development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
neurogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
pectoral fin development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
posterior lateral line development IMP
Inferred from Mutant Phenotype
more info
PubMed 
posterior lateral line neuromast deposition IMP
Inferred from Mutant Phenotype
more info
PubMed 
posterior lateral line neuromast development IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell proliferation involved in tissue homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of retinoic acid biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
somitogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
beta-catenin-TCF complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
lymphoid enhancer-binding factor 1
Names
etID310027.1
lymphocyte enhancer binding factor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131426.1NP_571501.1  lymphoid enhancer-binding factor 1

    See identical proteins and their annotated locations for NP_571501.1

    Status: PROVISIONAL

    Source sequence(s)
    AF136454
    UniProtKB/TrEMBL
    Q9W7C0
    Related
    ENSDARP00000114249.2, ENSDART00000132405.4
    Conserved Domains (2) summary
    cd01388
    Location:264335
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1210
    CTNNB1_binding; N-terminal CTNNB1 binding

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    49814548..49903487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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