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ephb4b eph receptor B4b [ Danio rerio (zebrafish) ]

Gene ID: 30691, updated on 22-Sep-2022

Summary

Official Symbol
ephb4bprovided by ZNC
Official Full Name
eph receptor B4bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-65
See related
Ensembl:ENSDARG00000027112 AllianceGenome:ZFIN:ZDB-GENE-990415-65
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
rtk8; cb417; EphB-rtk8
Summary
Predicted to enable ATP binding activity and ephrin receptor activity. Involved in somitogenesis. Acts upstream of or within Kupffer's vesicle development. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including anterior neural keel; central nervous system; forerunner cell group; neural tube; and tail bud. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human EPHB4 (EPH receptor B4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See ephb4b in Genome Data Viewer
Location:
chromosome: 23
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (44349830..44400916)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (44544426..44595512)
103 previous assembly Zv9 (GCF_000002035.4) 23 NC_007134.5 (44476466..44527722)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene methylphosphate capping enzyme b Neighboring gene discs, large homolog 4b (Drosophila) Neighboring gene eukaryotic translation initiation factor 4E family member 2 related sequence 1 Neighboring gene centrobin, centrosomal BRCA2 interacting protein

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ephrin type-B receptor 4b
Names
eph-like receptor tyrosine kinase 8
eph-like receptor tyrosine kinase rtk8
unp164
NP_571492.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131417.1NP_571492.1  ephrin type-B receptor 4b precursor

    See identical proteins and their annotated locations for NP_571492.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ005029
    UniProtKB/TrEMBL
    O73878
    Related
    ENSDARP00000088414.3, ENSDART00000097644.5
    Conserved Domains (5) summary
    cd05065
    Location:608876
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd00063
    Location:327431
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam14575
    Location:544608
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:25198
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
    cl15755
    Location:906969
    SAM_superfamily; SAM (Sterile alpha motif )

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    44349830..44400916
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)