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Bicd2 BICD cargo adaptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306809, updated on 21-Jul-2018

Summary

Official Symbol
Bicd2provided by RGD
Official Full Name
BICD cargo adaptor 2provided by RGD
Primary source
RGD:735093
See related
Ensembl:ENSRNOG00000016031
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
This gene encodes a dynein-dynactin adaptor protein. In mouse, the protein primarily localizes to the Golgi complex as well as to microtubule plus ends through dynactin. Overexpression studies suggest that the N-terminus mediates the dynein-dynactin interaction, while the C-terminus is responsible for Golgi targeting. Knockout of this gene in mouse results in a defect in cerebellar granule cell migration. In human, mutations in this gene are associated with spinal muscular dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Expression
Biased expression in Heart (RPKM 263.4), Lung (RPKM 200.6) and 9 other tissues See more
Orthologs

Genomic context

See Bicd2 in Genome Data Viewer
Location:
17p14
Exon count:
8
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (15673649..15718035, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (17731018..17775611, complement)

Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene inositol-pentakisphosphate 2-kinase Neighboring gene ribosomal protein S12-like Neighboring gene FYVE, RhoGEF and PH domain containing 3 Neighboring gene uncharacterized LOC108348606

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
Rab GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Rab GTPase binding ISO
Inferred from Sequence Orthology
more info
 
cytoskeletal adaptor activity IEA
Inferred from Electronic Annotation
more info
 
dynactin binding IEA
Inferred from Electronic Annotation
more info
 
dynactin binding ISO
Inferred from Sequence Orthology
more info
 
dynein complex binding IEA
Inferred from Electronic Annotation
more info
 
dynein complex binding ISO
Inferred from Sequence Orthology
more info
 
dynein light intermediate chain binding IEA
Inferred from Electronic Annotation
more info
 
dynein light intermediate chain binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
centrosome localization IEA
Inferred from Electronic Annotation
more info
 
centrosome localization ISO
Inferred from Sequence Orthology
more info
 
microtubule anchoring at microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
microtubule anchoring at microtubule organizing center ISO
Inferred from Sequence Orthology
more info
 
microtubule-based movement ISO
Inferred from Sequence Orthology
more info
 
minus-end-directed organelle transport along microtubule IEA
Inferred from Electronic Annotation
more info
 
minus-end-directed organelle transport along microtubule ISO
Inferred from Sequence Orthology
more info
 
protein localization to Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
protein localization to Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
regulation of microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
regulation of microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
retrograde vesicle-mediated transport, Golgi to ER IEA
Inferred from Electronic Annotation
more info
 
retrograde vesicle-mediated transport, Golgi to ER ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
annulate lamellae IEA
Inferred from Electronic Annotation
more info
 
annulate lamellae ISO
Inferred from Sequence Orthology
more info
 
centrosome IEA
Inferred from Electronic Annotation
more info
 
centrosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
nuclear pore IEA
Inferred from Electronic Annotation
more info
 
nuclear pore ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein bicaudal D homolog 2
Names
bicaudal D homolog 2
bicaudal D protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033674.2NP_001028846.1  protein bicaudal D homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_001028846.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (1).
    Source sequence(s)
    AC111847
    UniProtKB/TrEMBL
    Q496Z1
    Related
    ENSRNOP00000069365.1, ENSRNOT00000090647.1
    Conserved Domains (3) summary
    pfam09730
    Location:83797
    BicD; Microtubule-associated protein Bicaudal-D
    cl19219
    Location:55169
    DUF342; Protein of unknown function (DUF342)
    cl19252
    Location:178230
    MreC; rod shape-determining protein MreC
  2. NM_198765.3NP_942060.1  protein bicaudal D homolog 2 isoform 2

    See identical proteins and their annotated locations for NP_942060.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses alternate splice sites in the 3' coding region and differs in the 3' UTR compared to variant 1. It encodes isoform 2, which has a shorter C-terminus than isoform 1.
    Source sequence(s)
    AC111847
    UniProtKB/TrEMBL
    Q712J3
    Related
    ENSRNOP00000047890.4, ENSRNOT00000048653.4
    Conserved Domains (3) summary
    pfam09730
    Location:83797
    BicD; Microtubule-associated protein Bicaudal-D
    cl19219
    Location:55169
    DUF342; Protein of unknown function (DUF342)
    cl19252
    Location:178230
    MreC; rod shape-determining protein MreC

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

    Range
    15673649..15718035 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000085.1 Alternate Rn_Celera

    Range
    14990557..15035504 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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