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HDC histidine decarboxylase [ Homo sapiens (human) ]

Gene ID: 3067, updated on 15-Apr-2019

Summary

Official Symbol
HDCprovided by HGNC
Official Full Name
histidine decarboxylaseprovided by HGNC
Primary source
HGNC:HGNC:4855
See related
Ensembl:ENSG00000140287 MIM:142704
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.[provided by RefSeq, Aug 2010]
Expression
Broad expression in gall bladder (RPKM 9.0), stomach (RPKM 6.4) and 14 other tissues See more
Orthologs

Genomic context

See HDC in Genome Data Viewer
Location:
15q21.2
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (50241945..50266049, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (50534144..50558162, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATPase phospholipid transporting 8B4 (putative) Neighboring gene ATP8B4 intron CAGE-defined high expression enhancer Neighboring gene solute carrier family 27 member 2 Neighboring gene RNA, 7SL, cytoplasmic 494, pseudogene Neighboring gene GA binding protein transcription factor subunit beta 1 Neighboring gene GABPB1 intronic transcript Neighboring gene GABPB1 antisense RNA 1 Neighboring gene RNA, U6 small nuclear 94, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC163399

Gene Ontology Provided by GOA

Function Evidence Code Pubs
histidine decarboxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
catecholamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
histamine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
histamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
histamine biosynthetic process TAS
Traceable Author Statement
more info
 
histidine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
histidine metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
histidine decarboxylase
NP_001293075.1
NP_002103.2
XP_016877583.1
XP_016877584.1
XP_016877585.1
XP_016877586.1
XP_016877587.1
XP_016877588.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027487.1 RefSeqGene

    Range
    5001..29019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001306146.1NP_001293075.1  histidine decarboxylase isoform 2

    See identical proteins and their annotated locations for NP_001293075.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC022087, AK027221, BC144173
    Consensus CDS
    CCDS76754.1
    UniProtKB/Swiss-Prot
    P19113
    Related
    ENSP00000440252.1, ENST00000543581.5
    Conserved Domains (1) summary
    pfam00282
    Location:36381
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain
  2. NM_002112.4NP_002103.2  histidine decarboxylase isoform 1

    See identical proteins and their annotated locations for NP_002103.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL041199, M60445
    Consensus CDS
    CCDS10134.1
    UniProtKB/Swiss-Prot
    P19113
    Related
    ENSP00000267845.3, ENST00000267845.8
    Conserved Domains (1) summary
    pfam00282
    Location:36414
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    50241945..50266049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022097.1XP_016877586.1  histidine decarboxylase isoform X4

  2. XM_017022095.1XP_016877584.1  histidine decarboxylase isoform X2

  3. XM_017022094.1XP_016877583.1  histidine decarboxylase isoform X1

  4. XM_017022096.1XP_016877585.1  histidine decarboxylase isoform X3

  5. XM_017022098.1XP_016877587.1  histidine decarboxylase isoform X5

  6. XM_017022099.1XP_016877588.1  histidine decarboxylase isoform X6

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