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gsk3ab glycogen synthase kinase 3 alpha b [ Danio rerio (zebrafish) ]

Gene ID: 30664, updated on 3-Oct-2019

Summary

Official Symbol
gsk3abprovided by ZNC
Official Full Name
glycogen synthase kinase 3 alpha bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990714-3
See related
Ensembl:ENSDARG00000015681
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
Also known as
GSK3; gsk3a; GSK-3[a]; GSK-3[b]

Genomic context

See gsk3ab in Genome Data Viewer
Location:
chromosome: 16
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (11242384..11292151)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (11351467..11401249)
103 previous assembly Zv9 (GCF_000002035.4) 16 NC_007127.5 (12946276..12996006)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene capicua transcriptional repressor b Neighboring gene zinc finger protein 526 Neighboring gene zinc finger protein 574 Neighboring gene glutamate receptor, ionotropic, kainate 5 Neighboring gene uncharacterized LOC103908906 Neighboring gene uncharacterized LOC110437971

Genomic regions, transcripts, and products

Bibliography

Pathways from BioSystems

General gene information

Markers

Homology

  • Homologs of the gsk3ab gene: The gsk3ab gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
PubMed 
extrinsic apoptotic signaling pathway in absence of ligand IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heart looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of dendrite development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
glycogen synthase kinase-3 alpha
NP_571465.1
XP_009290361.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131390.2NP_571465.1  glycogen synthase kinase-3 alpha

    See identical proteins and their annotated locations for NP_571465.1

    Status: PROVISIONAL

    Source sequence(s)
    BC065952
    UniProtKB/TrEMBL
    Q9YH61
    Related
    ENSDARP00000011670.7, ENSDART00000024935.8
    Conserved Domains (1) summary
    cd14137
    Location:78370
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    11242384..11292151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009292086.3XP_009290361.1  glycogen synthase kinase-3 alpha isoform X1

    UniProtKB/TrEMBL
    F6P7Z4
    Conserved Domains (2) summary
    cd14137
    Location:78370
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
    pfam00069
    Location:83367
    Pkinase; Protein kinase domain
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