gsk3ab glycogen synthase kinase 3 alpha b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gsk3abprovided by ZNC
Official Full Name: glycogen synthase kinase 3 alpha bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990714-3
See related: Ensembl:ENSDARG00000015681 AllianceGenome:ZFIN:ZDB-GENE-990714-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: GSK3; gsk3a; GSK-3[a]; GSK-3[b]
Summary: Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within cardiac muscle cell development; dorsal/ventral pattern formation; and heart looping. Predicted to be active in axon; cytosol; and nucleus. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human GSK3A (glycogen synthase kinase 3 alpha). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (11242384..11292151)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (11351467..11401249)
103	previous assembly	Zv9 (GCF_000002035.4)	16	NC_007127.5 (12946276..12996006)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results found gsk3a to be a target for miR-34a which downregulates its expression by targeting its 3' UTR. The miR-34a/gsk3a interaction modulates sperm motility in zebrafish.
Title: miR-34a Regulates Sperm Motility in Zebrafish.
GSK3alpha, but not GSK3beta, is necessary in cardiomyocyte survival
Title: Glycogen synthase kinase 3 alpha and 3 beta have distinct functions during cardiogenesis of zebrafish embryo.
lycogen synthase kinase-3 (GSK3) was identified as a substrate of protein kinase c delta in breast cancer cells.
Title: Impact of PKCdelta on estrogen receptor localization and activity in breast cancer cells.

Submit: New GeneRIF Correction

General gene information

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Markers

gsk3a (e-PCR), detects polymorphism
- UniSTS:205620

Homology

Homologs of the gsk3ab gene: The gsk3ab gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 135 organisms have orthologs with zebrafish gene gsk3ab
Orthologs

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables tau-protein kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info
involved_in extrinsic apoptotic signaling pathway in absence of ligand	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of TOR signaling	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: glycogen synthase kinase 3 alpha b; glycogen synthase kinase-3 alpha

NP_571465.1

EC 2.7.11.26

XP_009290361.1

EC 2.7.11.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131390.2 → NP_571465.1 glycogen synthase kinase 3 alpha b

See identical proteins and their annotated locations for NP_571465.1

Status: PROVISIONAL

Source sequence(s)

BC065952

UniProtKB/TrEMBL

Q6NZV8, Q9YH61

Related

ENSDARP00000011670.7, ENSDART00000024935.8

Conserved Domains (1) summary

cd14137
Location:78 → 370

STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

11242384..11292151

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009292086.3 → XP_009290361.1 glycogen synthase kinase-3 alpha isoform X1

UniProtKB/TrEMBL

A0A8M3AQC2, F6P7Z4

Conserved Domains (2) summary

cd14137
Location:78 → 370

STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

pfam00069
Location:83 → 367

Pkinase; Protein kinase domain