U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Col4a2 collagen type IV alpha 2 chain [ Rattus norvegicus (Norway rat) ]

Gene ID: 306628, updated on 10-Jul-2024

Summary

Official Symbol
Col4a2provided by RGD
Official Full Name
collagen type IV alpha 2 chainprovided by RGD
Primary source
RGD:1308085
See related
EnsemblRapid:ENSRNOG00000023972 AllianceGenome:RGD:1308085
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be an extracellular matrix structural constituent. Involved in aging and response to activity. Predicted to be located in basement membrane. Predicted to be part of collagen type IV trimer. Predicted to be active in extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in atherosclerosis; brain small vessel disease 2; and porencephaly. Orthologous to human COL4A2 (collagen type IV alpha 2 chain). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 790.7), Lung (RPKM 732.5) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Col4a2 in Genome Data Viewer
Location:
16q12.5
Exon count:
48
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (84749672..84885520, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (78047591..78183360, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (83386388..83522169, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553902 Neighboring gene NAD(P)HX dehydratase Neighboring gene RAB20, member RAS oncogene family Neighboring gene collagen type IV alpha 1 chain Neighboring gene uncharacterized LOC134482537 Neighboring gene uncharacterized LOC120097569

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables extracellular matrix structural constituent conferring tensile strength IBA
Inferred from Biological aspect of Ancestor
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in basement membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
 
part_of collagen type IV trimer IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of collagen type IV trimer ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
collagen alpha-2(IV) chain
Names
alpha-2 collagen type IV
collagen, type IV, alpha 2
procollagen, type IV, alpha 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427256.1NP_001414185.1  collagen alpha-2(IV) chain precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A6IWQ1, F1M6Q3
    Related
    ENSRNOP00000054270.5, ENSRNOT00000057461.6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    84749672..84885520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)