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Mcph1 microcephalin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306594, updated on 18-Apr-2019

Summary

Official Symbol
Mcph1provided by RGD
Official Full Name
microcephalin 1provided by RGD
Primary source
RGD:1560642
See related
Ensembl:ENSRNOG00000028586
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560642
Expression
Biased expression in Thymus (RPKM 39.1), Spleen (RPKM 34.9) and 9 other tissues See more
Orthologs

Genomic context

See Mcph1 in Genome Data Viewer
Location:
16q12.5
Exon count:
16
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (75904087..76110624, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 16 NC_005115.3 (75508903..75716058, complement)

Chromosome 16 - NC_005115.4Genomic Context describing neighboring genes Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 5 Neighboring gene microtubule-associated protein 1 light chain 3 beta 2 Neighboring gene angiopoietin 2 Neighboring gene uncharacterized LOC108348423 Neighboring gene uncharacterized LOC108348424

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
bone development IEA
Inferred from Electronic Annotation
more info
 
bone development ISO
Inferred from Sequence Orthology
more info
PubMed 
cerebral cortex development IEA
Inferred from Electronic Annotation
more info
 
cerebral cortex development ISO
Inferred from Sequence Orthology
more info
PubMed 
establishment of mitotic spindle orientation IEA
Inferred from Electronic Annotation
more info
 
establishment of mitotic spindle orientation ISO
Inferred from Sequence Orthology
more info
PubMed 
mitotic cell cycle arrest IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle arrest ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
neuronal stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
neuronal stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
PubMed 
protein localization to centrosome IEA
Inferred from Electronic Annotation
more info
 
protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of centrosome cycle IEA
Inferred from Electronic Annotation
more info
 
regulation of centrosome cycle ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of chromosome condensation IEA
Inferred from Electronic Annotation
more info
 
regulation of chromosome condensation ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
microcephalin
Names
microcephaly, primary autosomal recessive 1

NCBI Reference Sequences (RefSeq)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005115.4 Reference Rnor_6.0 Primary Assembly

    Range
    75904087..76110624 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253383.3XP_006253445.1  microcephalin isoform X2

    Conserved Domains (4) summary
    cd00027
    Location:629691
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    pfam12258
    Location:246585
    Microcephalin; Microcephalin protein
    pfam12738
    Location:35101
    PTCB-BRCT; twin BRCT domain
    cl00038
    Location:741805
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
  2. XM_225006.9XP_225006.7  microcephalin isoform X1

    UniProtKB/TrEMBL
    D3ZJM7
    Related
    ENSRNOP00000046380.4, ENSRNOT00000043384.4
    Conserved Domains (4) summary
    cd00027
    Location:657719
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    pfam12258
    Location:246608
    Microcephalin; Microcephalin protein
    pfam12738
    Location:35101
    PTCB-BRCT; twin BRCT domain
    cl00038
    Location:769833
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
  3. XM_006253385.3XP_006253447.1  microcephalin isoform X3

    Conserved Domains (3) summary
    cd00027
    Location:597659
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    pfam12258
    Location:186548
    Microcephalin; Microcephalin protein
    cl00038
    Location:141
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
  4. XM_006253388.3XP_006253450.1  microcephalin isoform X4

    Conserved Domains (3) summary
    cd00027
    Location:657719
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    pfam12258
    Location:246608
    Microcephalin; Microcephalin protein
    pfam12738
    Location:35101
    PTCB-BRCT; twin BRCT domain

Alternate Rn_Celera

Genomic

  1. AC_000084.1 Alternate Rn_Celera

    Range
    68871372..69069330 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006222284.3XP_006222346.1  microcephalin isoform X2

    Conserved Domains (4) summary
    cd00027
    Location:629691
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    pfam12258
    Location:246585
    Microcephalin; Microcephalin protein
    pfam12738
    Location:35101
    PTCB-BRCT; twin BRCT domain
    cl00038
    Location:741805
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
  2. XM_001074501.6XP_001074501.4  microcephalin isoform X1

    See identical proteins and their annotated locations for XP_001074501.4

    Conserved Domains (4) summary
    cd00027
    Location:657719
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    pfam12258
    Location:246608
    Microcephalin; Microcephalin protein
    pfam12738
    Location:35101
    PTCB-BRCT; twin BRCT domain
    cl00038
    Location:769833
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
  3. XM_006222286.3XP_006222348.1  microcephalin isoform X3

    Conserved Domains (3) summary
    cd00027
    Location:597659
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    pfam12258
    Location:186548
    Microcephalin; Microcephalin protein
    cl00038
    Location:141
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
  4. XM_006222289.3XP_006222351.1  microcephalin isoform X4

    Conserved Domains (3) summary
    cd00027
    Location:657719
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    pfam12258
    Location:246608
    Microcephalin; Microcephalin protein
    pfam12738
    Location:35101
    PTCB-BRCT; twin BRCT domain
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