U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ank1 ankyrin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306570, updated on 13-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Ank1provided by RGD
Official Full Name
ankyrin 1provided by RGD
Primary source
RGD:1309620
See related
Ensembl:ENSRNOG00000018241 AllianceGenome:RGD:1309620
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including enzyme binding activity; spectrin binding activity; and transmembrane transporter binding activity. Involved in positive regulation of organelle organization. Located in several cellular components, including axolemma; sarcolemma; and sarcomere. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in anemia; hereditary spherocytosis; and hereditary spherocytosis type 1. Orthologous to human ANK1 (ankyrin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 210.6), Muscle (RPKM 101.7) and 3 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
16q12.5
Exon count:
49
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (75578824..75757464, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (68876294..69054963, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (73681422..73912605, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene glycerol-3-phosphate acyltransferase 4 Neighboring gene NK6 homeobox 3 Neighboring gene uncharacterized LOC120097525 Neighboring gene splicing regulatory glutamine/lysine-rich protein 1-like Neighboring gene lysine acetyltransferase 6A Neighboring gene uncharacterized LOC134482522 Neighboring gene uncharacterized LOC120097527

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Integrity of the network sarcoplasmic reticulum in skeletal muscle requires small ankyrin 1. Ackermann MA, et al. J Cell Sci, 2011 Nov 1. PMID 22045734, Free PMC Article
  2. Frequent de novo mutations of the ANK1 gene mimic a recessive mode of transmission in hereditary spherocytosis: three new ANK1 variants: ankyrins Bari, Napoli II and Anzio. Randon J, et al. Br J Haematol, 1997 Mar. PMID 9054656
  3. An isoform of ankyrin is localized at nodes of Ranvier in myelinated axons of central and peripheral nerves. Kordeli E, et al. J Cell Biol, 1990 Apr. PMID 2139035, Free PMC Article
  4. Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1. Hori S, et al. Nat Commun, 2023 May 11. PMID 37169739, Free PMC Article
  5. Identification of Small Ankyrin 1 as a Novel Sarco(endo)plasmic Reticulum Ca2+-ATPase 1 (SERCA1) Regulatory Protein in Skeletal Muscle. Desmond PF, et al. J Biol Chem, 2015 Nov 13. PMID 26405035, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1.
    Title: Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1.
  2. these results suggest that sAnk1 interacts with SERCA1 through its TM and cytoplasmic domains to regulate SERCA1 activity and modulate sequestration of Ca(2+) in the sarcoplasmic reticulum lumen.
    Title: Identification of Small Ankyrin 1 as a Novel Sarco(endo)plasmic Reticulum Ca2+-ATPase 1 (SERCA1) Regulatory Protein in Skeletal Muscle.
  3. Site-directed mutagenesis, blot overlays and surface plasmon resonance assays were used to study the contribution of the hydrophobic residues, V70, F71, I102 and I103 of small ankyrin-1 (sAnk1), to two different 30-mers of obscurin that bind sAnk1.
    Title: Hydrophobic residues in small ankyrin 1 participate in binding to obscurin.
  4. Ank1 stabilizes the network sarcoplasmic reticulum in skeletal muscl.
    Title: Integrity of the network sarcoplasmic reticulum in skeletal muscle requires small ankyrin 1.
  5. Obscurin and ank1.5 localization in developing rat diaphragm
    Title: Localization of ank1.5 in the sarcoplasmic reticulum precedes that of SERCA and RyR: relationship with the organization of obscurin in developing sarcomeres.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
  
enables cytoskeletal anchor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytoskeletal anchor activity ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables spectrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables spectrin binding ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within erythrocyte development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inorganic cation transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within porphyrin-containing compound biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of organelle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in A band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in M band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ankyrin-1 complex ISO
Inferred from Sequence Orthology
more info
  
located_in axolemma IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cortical cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sarcolemma IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spectrin-associated cytoskeleton ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ankyrin-1
Names
ankyrin 1, erythrocytic
ankyrin 1, erythroid

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395562.1 → NP_001382491.1  ankyrin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I5ZJ94
    Related
    ENSRNOP00000076708.1, ENSRNOT00000102914.1
    Conserved Domains (9) summary
    smart00218
    Location:952 → 1056
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA02875
    Location:415 → 625
    PHA02875; ankyrin repeat protein; Provisional
    PHA02876
    Location:123 → 468
    PHA02876; ankyrin repeat protein; Provisional
    cd08805
    Location:1442 → 1525
    Death_ank1; Death domain of Ankyrin-1
    sd00045
    Location:700 → 731
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:767 → 819
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1277 → 1406
    UPA_2; UPA domain
    pfam12796
    Location:49 → 140
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:579 → 792
    Ank_2; Ankyrin repeats (3 copies)

  2. NM_001395563.1 → NP_001382492.1  ankyrin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I6A0H1
    Related
    ENSRNOP00000084044.1, ENSRNOT00000094764.1
    Conserved Domains (9) summary
    smart00218
    Location:907 → 1011
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA02875
    Location:378 → 588
    PHA02875; ankyrin repeat protein; Provisional
    PHA02876
    Location:86 → 431
    PHA02876; ankyrin repeat protein; Provisional
    COG0666
    Location:5 → 163
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd08805
    Location:1397 → 1480
    Death_ank1; Death domain of Ankyrin-1
    sd00045
    Location:663 → 694
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:730 → 782
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1232 → 1361
    UPA_2; UPA domain
    cl39094
    Location:542 → 755
    Ank_2; Ankyrin repeats (3 copies)

  3. NM_001395564.1 → NP_001382493.1  ankyrin-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I5ZS64
    Related
    ENSRNOP00000081687.1, ENSRNOT00000094734.1
    Conserved Domains (9) summary
    smart00218
    Location:923 → 1027
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA02875
    Location:386 → 596
    PHA02875; ankyrin repeat protein; Provisional
    PHA02876
    Location:94 → 439
    PHA02876; ankyrin repeat protein; Provisional
    cd08805
    Location:1413 → 1496
    Death_ank1; Death domain of Ankyrin-1
    sd00045
    Location:671 → 702
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:738 → 790
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1248 → 1377
    UPA_2; UPA domain
    pfam12796
    Location:20 → 111
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:550 → 763
    Ank_2; Ankyrin repeats (3 copies)

  4. NM_001395565.1 → NP_001382494.1  ankyrin-1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    Conserved Domains (9) summary
    smart00218
    Location:907 → 1011
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA02875
    Location:378 → 588
    PHA02875; ankyrin repeat protein; Provisional
    PHA02876
    Location:86 → 431
    PHA02876; ankyrin repeat protein; Provisional
    COG0666
    Location:5 → 163
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd08805
    Location:1397 → 1480
    Death_ank1; Death domain of Ankyrin-1
    sd00045
    Location:663 → 694
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:730 → 782
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1232 → 1361
    UPA_2; UPA domain
    cl39094
    Location:542 → 755
    Ank_2; Ankyrin repeats (3 copies)

  5. NM_001395566.1 → NP_001382495.1  ankyrin-1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I6ABK4
    Related
    ENSRNOP00000091410.1, ENSRNOT00000095662.1
    Conserved Domains (9) summary
    smart00218
    Location:923 → 1027
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA02875
    Location:386 → 596
    PHA02875; ankyrin repeat protein; Provisional
    PHA02876
    Location:94 → 439
    PHA02876; ankyrin repeat protein; Provisional
    cd08805
    Location:1413 → 1496
    Death_ank1; Death domain of Ankyrin-1
    sd00045
    Location:671 → 702
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:738 → 790
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1248 → 1377
    UPA_2; UPA domain
    pfam12796
    Location:20 → 111
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:550 → 763
    Ank_2; Ankyrin repeats (3 copies)

  6. NM_001395567.1 → NP_001382496.1  ankyrin-1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    Related
    ENSRNOP00000062056.2, ENSRNOT00000064070.3
    Conserved Domains (9) summary
    smart00218
    Location:923 → 1027
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA02875
    Location:386 → 596
    PHA02875; ankyrin repeat protein; Provisional
    PHA02876
    Location:94 → 439
    PHA02876; ankyrin repeat protein; Provisional
    cd08805
    Location:1413 → 1496
    Death_ank1; Death domain of Ankyrin-1
    sd00045
    Location:671 → 702
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:738 → 790
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1248 → 1377
    UPA_2; UPA domain
    pfam12796
    Location:20 → 111
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:550 → 763
    Ank_2; Ankyrin repeats (3 copies)

  7. NM_001395568.1 → NP_001382497.1  ankyrin-1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    Conserved Domains (9) summary
    smart00218
    Location:944 → 1048
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA02875
    Location:415 → 625
    PHA02875; ankyrin repeat protein; Provisional
    PHA02876
    Location:123 → 468
    PHA02876; ankyrin repeat protein; Provisional
    cd08805
    Location:1434 → 1517
    Death_ank1; Death domain of Ankyrin-1
    sd00045
    Location:700 → 731
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:767 → 819
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1269 → 1398
    UPA_2; UPA domain
    pfam12796
    Location:49 → 140
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:579 → 792
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    75578824..75757464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094577.2 → XP_038950505.1  ankyrin-1 isoform X15

    Conserved Domains (9) summary
    smart00218
    Location:952 → 1056
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA02875
    Location:415 → 625
    PHA02875; ankyrin repeat protein; Provisional
    PHA02876
    Location:123 → 468
    PHA02876; ankyrin repeat protein; Provisional
    cd08805
    Location:1442 → 1525
    Death_ank1; Death domain of Ankyrin-1
    sd00045
    Location:700 → 731
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:767 → 819
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1277 → 1406
    UPA_2; UPA domain
    pfam12796
    Location:49 → 140
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:579 → 792
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_039094571.2 → XP_038950499.1  ankyrin-1 isoform X7

    Conserved Domains (9) summary
    smart00218
    Location:952 → 1056
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA02875
    Location:415 → 625
    PHA02875; ankyrin repeat protein; Provisional
    PHA02876
    Location:123 → 468
    PHA02876; ankyrin repeat protein; Provisional
    cd08805
    Location:1442 → 1525
    Death_ank1; Death domain of Ankyrin-1
    sd00045
    Location:700 → 731
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:767 → 819
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1277 → 1406
    UPA_2; UPA domain
    pfam12796
    Location:49 → 140
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:579 → 792
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_039094582.2 → XP_038950510.2  ankyrin-1 isoform X20

  4. XM_063275451.1 → XP_063131521.1  ankyrin-1 isoform X16

  5. XM_063275448.1 → XP_063131518.1  ankyrin-1 isoform X11

  6. XM_039094574.2 → XP_038950502.2  ankyrin-1 isoform X10

  7. XM_039094569.2 → XP_038950497.2  ankyrin-1 isoform X6

  8. XM_039094581.2 → XP_038950509.2  ankyrin-1 isoform X19

  9. XM_039094568.2 → XP_038950496.2  ankyrin-1 isoform X5

  10. XM_063275450.1 → XP_063131520.1  ankyrin-1 isoform X14

  11. XM_039094566.2 → XP_038950494.2  ankyrin-1 isoform X4

  12. XM_039094572.2 → XP_038950500.2  ankyrin-1 isoform X8

  13. XM_039094565.2 → XP_038950493.2  ankyrin-1 isoform X3

  14. XM_039094564.2 → XP_038950492.2  ankyrin-1 isoform X2

  15. XM_039094562.2 → XP_038950490.2  ankyrin-1 isoform X1

  16. XM_063275453.1 → XP_063131523.1  ankyrin-1 isoform X18

  17. XM_063275452.1 → XP_063131522.1  ankyrin-1 isoform X17

    UniProtKB/TrEMBL
    A0A8I6GAS7

  18. XM_063275449.1 → XP_063131519.1  ankyrin-1 isoform X13

  19. XM_039094576.2 → XP_038950504.1  ankyrin-1 isoform X12

    Conserved Domains (9) summary
    smart00218
    Location:923 → 1027
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA02875
    Location:386 → 596
    PHA02875; ankyrin repeat protein; Provisional
    PHA02876
    Location:94 → 439
    PHA02876; ankyrin repeat protein; Provisional
    cd08805
    Location:1413 → 1496
    Death_ank1; Death domain of Ankyrin-1
    sd00045
    Location:671 → 702
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:738 → 790
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1248 → 1377
    UPA_2; UPA domain
    pfam12796
    Location:20 → 111
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:550 → 763
    Ank_2; Ankyrin repeats (3 copies)

  20. XM_063275454.1 → XP_063131524.1  ankyrin-1 isoform X21

    UniProtKB/TrEMBL
    A0A8I5ZQ60

  21. XM_039094585.2 → XP_038950513.1  ankyrin-1 isoform X23

    Related
    ENSRNOP00000080599.1

  22. XM_039094584.2 → XP_038950512.1  ankyrin-1 isoform X22

  23. XM_063275447.1 → XP_063131517.1  ankyrin-1 isoform X9

RNA

  1. XR_005494624.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107322.2: Suppressed sequence

    Description
    NM_001107322.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous