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Tacc1 transforming, acidic coiled-coil containing protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306562, updated on 18-Sep-2024

Summary

Official Symbol
Tacc1provided by RGD
Official Full Name
transforming, acidic coiled-coil containing protein 1provided by RGD
Primary source
RGD:1303120
See related
EnsemblRapid:ENSRNOG00000016423 AllianceGenome:RGD:1303120
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tacc1a
Summary
This gene encodes a member of the transforming, acidic coiled-coil (TACC) family of proteins. Members of this family are centrosomal proteins that interact with microtubules and tubulin. TACC proteins are thought to be involved in centrosome/mitotic spindle dynamics and gene regulation. [provided by RefSeq, Jul 2008]
Expression
Biased expression in Adrenal (RPKM 234.3), Spleen (RPKM 204.6) and 9 other tissues See more
Orthologs
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Genomic context

See Tacc1 in Genome Data Viewer
Location:
16q12.4
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (73515016..73598395)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (66812232..66895736)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (71596970..71681126)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482518 Neighboring gene ribosomal protein S28, pseudogene 1 Neighboring gene pleckstrin homology domain containing A2 Neighboring gene uncharacterized LOC134482519 Neighboring gene HtrA serine peptidase 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear glucocorticoid receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables nuclear retinoic acid receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear retinoid X receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear thyroid hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables peroxisome proliferator activated receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in cerebral cortex development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cerebral cortex development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within interkinetic nuclear migration ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic spindle organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neurogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of microtubule-based process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transforming acidic coiled-coil-containing protein 1
Names
transforming, acidic coiled-coil containing protein 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004107.4NP_001004107.1  transforming acidic coiled-coil-containing protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    D4A927
    Related
    ENSRNOP00000030626.4, ENSRNOT00000035347.7
    Conserved Domains (3) summary
    pfam05010
    Location:566765
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam09403
    Location:671764
    FadA; Adhesion protein FadA
    cl21478
    Location:573658
    ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    73515016..73598395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094561.2XP_038950489.2  transforming acidic coiled-coil-containing protein 1 isoform X7

  2. XM_063275446.1XP_063131516.1  transforming acidic coiled-coil-containing protein 1 isoform X6

  3. XM_017600146.3XP_017455635.1  transforming acidic coiled-coil-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    D4A927
  4. XM_039094559.2XP_038950487.1  transforming acidic coiled-coil-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AHG9, D4A927
    Related
    ENSRNOP00000092100.2, ENSRNOT00000106912.2
    Conserved Domains (1) summary
    pfam05010
    Location:536735
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  5. XM_063275445.1XP_063131515.1  transforming acidic coiled-coil-containing protein 1 isoform X5

    UniProtKB/TrEMBL
    D4A927
  6. XM_063275444.1XP_063131514.1  transforming acidic coiled-coil-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    D4A927
  7. XM_017600145.3XP_017455634.1  transforming acidic coiled-coil-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K9K2, D4A927
    Related
    ENSRNOP00000075027.1, ENSRNOT00000088462.3
  8. XM_006253318.5XP_006253380.1  transforming acidic coiled-coil-containing protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A8I5Y233
    Related
    ENSRNOP00000078214.1, ENSRNOT00000097760.2
    Conserved Domains (1) summary
    pfam05010
    Location:161360
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  9. XM_063275443.1XP_063131513.1  transforming acidic coiled-coil-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K9K2, D4A927