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Unc5d unc-5 netrin receptor D [ Rattus norvegicus (Norway rat) ]

Gene ID: 306534, updated on 15-May-2025
Official Symbol
Unc5dprovided by RGD
Official Full Name
unc-5 netrin receptor Dprovided by RGD
Primary source
RGD:1309245
See related
Ensembl:ENSRNOG00000011858 AllianceGenome:RGD:1309245
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable netrin receptor activity. Predicted to be involved in axon guidance and cell-cell adhesion via plasma-membrane adhesion molecules. Predicted to act upstream of or within pyramidal neuron differentiation and regulation of neuron migration. Predicted to be located in cell surface. Orthologous to human UNC5D (unc-5 netrin receptor D). [provided by Alliance of Genome Resources, May 2025]
Expression
Biased expression in Brain (RPKM 66.7), Adrenal (RPKM 25.7) and 5 other tissues See more
Orthologs
human mouse all
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See Unc5d in Genome Data Viewer
Location:
16q12.3
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (69563099..70109862)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (62860119..63406932)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (67047803..67601002)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097502 Neighboring gene ribosomal protein S20, pseudogene 8 Neighboring gene transfer RNA leucine (anticodon AAG) 8 Neighboring gene U2 spliceosomal RNA Neighboring gene transfer RNA serine (anticodon AGA) 51 Neighboring gene NME/NM23 nucleoside diphosphate kinase 1, pseudogene 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. The cortical subventricular zone-specific molecule Svet1 is part of the nuclear RNA coded by the putative netrin receptor gene Unc5d and is expressed in multipolar migrating cells. Sasaki S, et al. Mol Cell Neurosci, 2008 Aug. PMID 18547816
  2. Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion. Lu YC, et al. Structure, 2015 Sep 1. PMID 26235030, Free PMC Article
  3. FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons. Yamagishi S, et al. EMBO J, 2011 Jun 14. PMID 21673655, Free PMC Article
  4. Dynamic FoxG1 expression coordinates the integration of multipolar pyramidal neuron precursors into the cortical plate. Miyoshi G, et al. Neuron, 2012 Jun 21. PMID 22726835, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables netrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables netrin receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axon guidance IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within axon guidance ISO
Inferred from Sequence Orthology
more info
  
involved_in cell-cell adhesion via plasma-membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
involved_in netrin-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pyramidal neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of neuron migration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
netrin receptor UNC5D
Names
protein unc-5 homolog D
unc-5 homolog D

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107319.2 → NP_001100789.2  netrin receptor UNC5D precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/Swiss-Prot
    F1LW30
    UniProtKB/TrEMBL
    A0A0R3P9D5
    Related
    ENSRNOP00000077568.1, ENSRNOT00000111680.2
    Conserved Domains (5) summary
    cd08801
    Location:856 → 953
    Death_UNC5D; Death domain found in Uncoordinated-5D
    smart00209
    Location:253 → 304
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:159 → 247
    I-set; Immunoglobulin I-set domain
    pfam00791
    Location:545 → 640
    ZU5; ZU5 domain
    cl11960
    Location:161 → 247
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    69563099..70109862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017600136.3 → XP_017455625.1  netrin receptor UNC5D isoform X2

    UniProtKB/TrEMBL
    A0A0R3P9D5

  2. XM_017600138.3 → XP_017455627.1  netrin receptor UNC5D isoform X5

    UniProtKB/TrEMBL
    A0A0R3P9D5

  3. XM_039094549.2 → XP_038950477.1  netrin receptor UNC5D isoform X7

    UniProtKB/TrEMBL
    A0A0R3P9D5
    Conserved Domains (6) summary
    cd08801
    Location:784 → 881
    Death_UNC5D; Death domain found in Uncoordinated-5D
    smart00209
    Location:253 → 301
    TSP1; Thrombospondin type 1 repeats
    pfam00791
    Location:474 → 570
    ZU5; ZU5 domain
    pfam17217
    Location:618 → 757
    UPA; UPA domain
    cd00096
    Location:165 → 169
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:161 → 247
    Ig; Immunoglobulin domain

  4. XM_017600135.3 → XP_017455624.1  netrin receptor UNC5D isoform X1

    UniProtKB/TrEMBL
    A0A0G2KA37, A0A0R3P9D5
    Related
    ENSRNOP00000075244.2, ENSRNOT00000085659.3

  5. XM_017600137.3 → XP_017455626.1  netrin receptor UNC5D isoform X4

    UniProtKB/TrEMBL
    A0A0R3P9D5

  6. XM_039094548.2 → XP_038950476.1  netrin receptor UNC5D isoform X3

    UniProtKB/TrEMBL
    A0A0R3P9D5
    Related
    ENSRNOP00000100052.1, ENSRNOT00000125236.1
    Conserved Domains (6) summary
    cd08801
    Location:840 → 937
    Death_UNC5D; Death domain found in Uncoordinated-5D
    smart00209
    Location:253 → 304
    TSP1; Thrombospondin type 1 repeats
    pfam00791
    Location:530 → 626
    ZU5; ZU5 domain
    pfam17217
    Location:674 → 813
    UPA; UPA domain
    cd00096
    Location:165 → 169
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:161 → 247
    Ig; Immunoglobulin domain

  7. XM_017600139.3 → XP_017455628.1  netrin receptor UNC5D isoform X6

    UniProtKB/TrEMBL
    A0A0R3P9D5
    Related
    ENSRNOP00000104754.1, ENSRNOT00000123536.1

  8. XM_017600140.3 → XP_017455629.1  netrin receptor UNC5D isoform X8

    UniProtKB/TrEMBL
    A0A0R3P9D5
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1LW30.4 GenPept UniProtKB/Swiss-Prot:F1LW30

Gene LinkOut

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