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cd74b CD74 molecule, major histocompatibility complex, class II invariant chain b [ Danio rerio (zebrafish) ]

Gene ID: 30645, updated on 9-Sep-2025
Official Symbol
cd74bprovided by ZNC
Official Full Name
CD74 molecule, major histocompatibility complex, class II invariant chain bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990910-10
See related
Ensembl:ENSDARG00000036628 AllianceGenome:ZFIN:ZDB-GENE-990910-10
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cd74; iclp2; Iclp-2; zgc:123161
Summary
Predicted to enable MHC class II protein binding activity; cytokine receptor activity; and macrophage migration inhibitory factor binding activity. Acts upstream of or within inner ear development and neuromast development. Predicted to be located in extracellular region and membrane. Predicted to be active in cell surface and cytoplasm. Is expressed in inner ear and otic vesicle. Orthologous to human CD74 (CD74 molecule). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See cd74b in Genome Data Viewer
Location:
chromosome: 21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 21 NC_133196.1 (36129856..36134127)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 21 NC_007132.7 (33459562..33463893)

Chromosome 21 - NC_133196.1Genomic Context describing neighboring genes Neighboring gene N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1b Neighboring gene uncharacterized LOC141380029 Neighboring gene SLC35A4 upstream open reading frame protein-like Neighboring gene ribosomal protein S14 Neighboring gene uncharacterized LOC141380030

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Antigen presentation plays positive roles in the regenerative response to cardiac injury in zebrafish. Cardeira-da-Silva J, et al. Nat Commun, 2024 Apr 29. PMID 38684665, Free PMC Article
  2. Ancient features of the MHC class II presentation pathway, and a model for the possible origin of MHC molecules. Dijkstra JM, et al. Immunogenetics, 2019 Mar. PMID 30377750
  3. The cytokine macrophage migration inhibitory factor (MIF) acts as a neurotrophin in the developing inner ear of the zebrafish, Danio rerio. Shen YC, et al. Dev Biol, 2012 Mar 1. PMID 22210003, Free PMC Article
  4. Zebrafish Model for Functional Screening of Flow-Responsive Genes. Serbanovic-Canic J, et al. Arterioscler Thromb Vasc Biol, 2017 Jan. PMID 27834691, Free PMC Article
  5. Early embryonic gene expression profiling of zebrafish prion protein (Prp2) morphants. Nourizadeh-Lillabadi R, et al. PLoS One, 2010 Oct 22. PMID 21042590, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Clone Names

  • MGC123161, MGC158500

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables MHC class II protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MHC class II protein binding IEA
Inferred from Electronic Annotation
more info
  
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables macrophage migration inhibitory factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables macrophage migration inhibitory factor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in T cell activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in antigen processing and presentation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within antigen processing and presentation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within inner ear development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuromast development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of macrophage cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of type 2 immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
CD74 molecule, major histocompatibility complex, class II invariant chain b
Names
invariant chain-like protein 2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131372.2 → NP_571447.1  CD74 molecule, major histocompatibility complex, class II invariant chain b

    See identical proteins and their annotated locations for NP_571447.1

    Status: PROVISIONAL

    Source sequence(s)
    BC127569
    UniProtKB/TrEMBL
    A1L140, Q9PVD9
    Related
    ENSDARP00000053204.4, ENSDART00000053205.6
    Conserved Domains (2) summary
    cd00191
    Location:121 → 179
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    pfam09307
    Location:10 → 100
    MHC2-interact; CLIP, MHC2 interacting

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133196.1 Reference GRCz12tu Primary Assembly

    Range
    36129856..36134127
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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