Naf1 nuclear assembly factor 1 ribonucleoprotein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Naf1provided by RGD
Official Full Name: nuclear assembly factor 1 ribonucleoproteinprovided by RGD
Primary source: RGD:1306802
See related: Ensembl:ENSRNOG00000026403 AllianceGenome:RGD:1306802
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1306802
Summary: Predicted to enable identical protein binding activity and telomerase RNA binding activity. Predicted to be involved in protein-RNA complex assembly; ribosome biogenesis; and telomerase RNA stabilization. Predicted to act upstream of or within telomerase RNA localization to Cajal body. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of sno(s)RNA-containing ribonucleoprotein complex. Human ortholog(s) of this gene implicated in melanoma. Orthologous to human NAF1 (nuclear assembly factor 1 ribonucleoprotein). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Brain (RPKM 37.3), Thymus (RPKM 32.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p14

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (27604228..27634963, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (22837583..22868320, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (24582000..24612773, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables telomerase RNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA stabilization	IEA Inferred from Electronic Annotation more info
involved_in RNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in RNA stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in box H/ACA snoRNP assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in box H/ACA snoRNP assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of telomere maintenance via telomere lengthening	ISO Inferred from Sequence Orthology more info
involved_in protein-RNA complex assembly	IEA Inferred from Electronic Annotation more info
involved_in pseudouridine synthesis	IEA Inferred from Electronic Annotation more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in ribosome biogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info
involved_in ribosome biogenesis	ISO Inferred from Sequence Orthology more info
involved_in ribosome biogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in telomerase RNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in telomerase holoenzyme complex assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of sno(s)RNA-containing ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of sno(s)RNA-containing ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of sno(s)RNA-containing ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
part_of sno(s)RNA-containing ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: H/ACA ribonucleoprotein complex non-core subunit NAF1

Names: nuclear assembly factor 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024772.2 → NP_001019943.1 H/ACA ribonucleoprotein complex non-core subunit NAF1

See identical proteins and their annotated locations for NP_001019943.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

Q52KK4

UniProtKB/TrEMBL

F1LMR4

Related

ENSRNOP00000031163.8, ENSRNOT00000033916.8

Conserved Domains (2) summary

pfam04410
Location:145 → 293

Gar1; Gar1/Naf1 RNA binding region

cl23807
Location:1 → 77

WWbp; WW-domain ligand protein