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mdm2 MDM2 proto-oncogene [ Danio rerio (zebrafish) ]

Gene ID: 30637, updated on 21-Jul-2019

Summary

Official Symbol
mdm2provided by ZNC
Official Full Name
MDM2 proto-oncogeneprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-153
See related
Ensembl:ENSDARG00000033443
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
Also known as
sb:eu923; zgc:109834
Orthologs

Genomic context

See mdm2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (23125732..23135272)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (23404700..23414304)
103 previous assembly Zv9 (GCF_000002035.4) 4 NC_007115.5 (22061395..22071817)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene membrane associated guanylate kinase, WW and PDZ domain containing 2a Neighboring gene solute carrier family 35 member E3 Neighboring gene thyrotropin releasing hormone degrading enzyme, tandem duplicate 1 Neighboring gene thyrotropin releasing hormone degrading enzyme, tandem duplicate 2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC109834, MGC113866, MGC192439

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell cycle arrest IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell cycle arrest IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
pronephric glomerulus morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of protein stability IGI
Inferred from Genetic Interaction
more info
PubMed 
response to X-ray IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase Mdm2
Names
MDM2 oncogene, E3 ubiquitin protein ligase
RING-type E3 ubiquitin transferase Mdm2
double minute 2 protein
etID309863.4
murine double minute 2 homolog
p53-binding protein Mdm2
transformed 3T3 cell double minute 2 homolog
XP_005164901.1
XP_005164902.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365432.1NP_001352361.1  E3 ubiquitin-protein ligase Mdm2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL929141
    Conserved Domains (3) summary
    pfam00641
    Location:286312
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam02201
    Location:2182
    SWIB; SWIB/MDM2 domain
    cd16783
    Location:430486
    mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins
  2. NM_131364.3NP_571439.3  E3 ubiquitin-protein ligase Mdm2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL929141, AL935183
    Related
    ENSDARP00000072320.4, ENSDART00000077854.6
    Conserved Domains (3) summary
    pfam00641
    Location:275301
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam02201
    Location:2182
    SWIB; SWIB/MDM2 domain
    cd16783
    Location:419475
    mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    23125732..23135272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005164844.4XP_005164901.1  E3 ubiquitin-protein ligase Mdm2 isoform X1

    See identical proteins and their annotated locations for XP_005164901.1

    UniProtKB/TrEMBL
    F6NS64
    Conserved Domains (3) summary
    pfam00641
    Location:286312
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam02201
    Location:2182
    SWIB; SWIB/MDM2 domain
    cd16783
    Location:430486
    mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins
  2. XM_005164845.4XP_005164902.1  E3 ubiquitin-protein ligase Mdm2 isoform X1

    See identical proteins and their annotated locations for XP_005164902.1

    UniProtKB/TrEMBL
    F6NS64
    Related
    ENSDARP00000138060.2, ENSDART00000162859.2
    Conserved Domains (3) summary
    pfam00641
    Location:286312
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam02201
    Location:2182
    SWIB; SWIB/MDM2 domain
    cd16783
    Location:430486
    mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395231.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    301057..310427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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