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Gmip Gem-interacting protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 306357, updated on 8-Apr-2026
Official Symbol
Gmipprovided by RGD
Official Full Name
Gem-interacting proteinprovided by RGD
Primary source
RGD:1565577
See related
Ensembl:ENSRNOG00000027257 AllianceGenome:RGD:1565577
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565577
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in intracellular signal transduction; negative regulation of GTPase activity; and negative regulation of small GTPase mediated signal transduction. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in plasma membrane. Orthologous to human GMIP (GEM interacting protein). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Spleen (RPKM 89.2), Thymus (RPKM 64.2) and 9 other tissues See more
Orthologs
Try the new Gene page
Try the new Transcripts and proteins table
See Gmip in Genome Data Viewer
Location:
16p14
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (19634630..19648916, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (19600723..19614459, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (21349652..21363412, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene PBX homeobox 4 Neighboring gene lysophosphatidic acid receptor 2 Neighboring gene ATPase 13A1 Neighboring gene zinc finger protein 709-like Neighboring gene U4 spliceosomal RNA

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of small GTPase mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in small GTPase-mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
GEM-interacting protein

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107308.1NP_001100778.1  GEM-interacting protein

    See identical proteins and their annotated locations for NP_001100778.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474031
    UniProtKB/TrEMBL
    A6KAB5, D3ZA46
    Related
    ENSRNOP00000034819.3, ENSRNOT00000039607.5
    Conserved Domains (3) summary
    smart00109
    Location:489534
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cl02570
    Location:546749
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl12013
    Location:111311
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    19634630..19648916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006252903.5XP_006252965.1  GEM-interacting protein isoform X1

    Conserved Domains (3) summary
    smart00109
    Location:486531
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cl02570
    Location:543746
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl12013
    Location:111311
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. XM_039094492.2XP_038950420.1  GEM-interacting protein isoform X2

    Conserved Domains (3) summary
    cd20816
    Location:489538
    C1_GMIP-like; protein kinase C conserved region 1 (C1 domain) found in the GEM-interacting protein (GMIP)-like family
    cl02570
    Location:546700
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl12013
    Location:111311
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  3. XM_039094493.2XP_038950421.1  GEM-interacting protein isoform X3

    Conserved Domains (3) summary
    cd20816
    Location:489538
    C1_GMIP-like; protein kinase C conserved region 1 (C1 domain) found in the GEM-interacting protein (GMIP)-like family
    cl02570
    Location:546626
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl12013
    Location:111311
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature