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Klf2 Kruppel-like factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306330, updated on 30-Sep-2021

Summary

Official Symbol
Klf2provided by RGD
Official Full Name
Kruppel-like factor 2provided by RGD
Primary source
RGD:1359220
See related
EnsemblRapid:ENSRNOG00000067705
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lklf
Expression
Biased expression in Lung (RPKM 112.1), Spleen (RPKM 85.5) and 8 other tissues See more
Orthologs
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Genomic context

See Klf2 in Genome Data Viewer
Location:
16p14
Exon count:
3
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (17521773..17523723, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (19223087..19225037, complement)

Chromosome 16 - NC_051351.1Genomic Context describing neighboring genes Neighboring gene similar to 1700030K09Rik protein Neighboring gene calreticulin 3 Neighboring gene epidermal growth factor receptor pathway substrate 15-like 1 Neighboring gene uncharacterized LOC120097429 Neighboring gene adaptor related protein complex 1 subunit mu 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cycloheximide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to fluid shear stress ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to laminar fluid shear stress ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to peptide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular stress response to acid chemical ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within erythrocyte homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within erythrocyte maturation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of retinoic acid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription from RNA polymerase II promoter in response to stress ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of gene expression, epigenetic ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to laminar fluid shear stress IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within type I pneumocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of vasodilation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
Krueppel-like factor 2
Names
Kruppel-like factor 2 (lung)
lung Kruppel-like factor
lung krueppel-like factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007684.1NP_001007685.1  Krueppel-like factor 2

    See identical proteins and their annotated locations for NP_001007685.1

    Status: PROVISIONAL

    Source sequence(s)
    AF181251
    UniProtKB/Swiss-Prot
    Q9ET58
    Related
    ENSRNOP00000083422.1, ENSRNOT00000112398.1
    Conserved Domains (4) summary
    COG5048
    Location:266346
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:270292
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:268292
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:314339
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051351.1 Reference mRatBN7.2 Primary Assembly

    Range
    17521773..17523723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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