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Klf2 Kruppel-like factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306330, updated on 2-Oct-2018

Summary

Official Symbol
Klf2provided by RGD
Official Full Name
Kruppel-like factor 2provided by RGD
Primary source
RGD:1359220
See related
Ensembl:ENSRNOG00000014205
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lklf
Expression
Biased expression in Lung (RPKM 112.1), Spleen (RPKM 85.5) and 8 other tissues See more
Orthologs

Genomic context

See Klf2 in Genome Data Viewer
Location:
16p14
Exon count:
3
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (19223087..19225037, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 16 NC_005115.3 (19084196..19086146, complement)

Chromosome 16 - NC_005115.4Genomic Context describing neighboring genes Neighboring gene calreticulin 3 Neighboring gene epidermal growth factor receptor pathway substrate 15-like 1 Neighboring gene adaptor related protein complex 1 subunit mu 1 Neighboring gene family with sequence similarity 32, member A

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Apelin signaling pathway, organism-specific biosystem (from KEGG)
    Apelin signaling pathway, organism-specific biosystemApelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various ti...
  • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • FoxO signaling pathway, organism-specific biosystem (from KEGG)
    FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cellular response to cycloheximide IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to fluid shear stress ISO
Inferred from Sequence Orthology
more info
 
cellular response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to laminar fluid shear stress IEA
Inferred from Electronic Annotation
more info
 
cellular response to laminar fluid shear stress ISO
Inferred from Sequence Orthology
more info
 
cellular response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to peptide IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
PubMed 
cellular stress response to acid chemical IEA
Inferred from Electronic Annotation
more info
 
cellular stress response to acid chemical ISO
Inferred from Sequence Orthology
more info
 
erythrocyte homeostasis ISO
Inferred from Sequence Orthology
more info
 
erythrocyte maturation IEA
Inferred from Electronic Annotation
more info
 
erythrocyte maturation ISO
Inferred from Sequence Orthology
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter in response to stress IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter in response to stress ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of gene expression, epigenetic IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression, epigenetic ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to laminar fluid shear stress IEP
Inferred from Expression Pattern
more info
PubMed 
type I pneumocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
type I pneumocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
nuclear chromatin IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
Krueppel-like factor 2
Names
Kruppel-like factor 2 (lung)
lung Kruppel-like factor
lung krueppel-like factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007684.1NP_001007685.1  Krueppel-like factor 2

    See identical proteins and their annotated locations for NP_001007685.1

    Status: PROVISIONAL

    Source sequence(s)
    AF181251
    UniProtKB/Swiss-Prot
    Q9ET58
    Related
    ENSRNOP00000019052.1, ENSRNOT00000019052.2
    Conserved Domains (4) summary
    COG5048
    Location:266346
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:270292
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:268292
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:314339
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005115.4 Reference Rnor_6.0 Primary Assembly

    Range
    19223087..19225037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000084.1 Alternate Rn_Celera

    Range
    17739313..17741263 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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