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Capn7 calpain 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306260, updated on 5-Mar-2024

Summary

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Official Symbol
Capn7provided by RGD
Official Full Name
calpain 7provided by RGD
Primary source
RGD:1304855
See related
Ensembl:ENSRNOG00000019273 AllianceGenome:RGD:1304855
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable MIT domain binding activity and endopeptidase activity. Predicted to be involved in positive regulation of epithelial cell migration and self proteolysis. Predicted to be located in centrosome and cytosol. Orthologous to human CAPN7 (calpain 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 122.2), Kidney (RPKM 118.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
16p16
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (6552048..6588317)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (6545630..6581908)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (7435541..7472483)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene GDP-mannose 4, 6-dehydratase, pseudogene 1 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene SH3-domain binding protein 5 Neighboring gene uncharacterized LOC134482448 Neighboring gene uncharacterized LOC134482449

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CAPN 7 promotes the migration and invasion of human endometrial stromal cell by regulating matrix metalloproteinase 2 activity. Liu H, et al. Reprod Biol Endocrinol, 2013 Jul 15. PMID 23855590, Free PMC Article
  2. Autolytic activity of human calpain 7 is enhanced by ESCRT-III-related protein IST1 through MIT-MIM interaction. Osako Y, et al. FEBS J, 2010 Nov. PMID 20849418
  3. Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus. Gafni J, et al. J Biol Chem, 2004 May 7. PMID 14981075
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC124688

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables MIT domain binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium-dependent cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in self proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
calpain-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030037.1 → NP_001025208.1  calpain-7

    See identical proteins and their annotated locations for NP_001025208.1

    Status: PROVISIONAL

    Source sequence(s)
    BC099770
    UniProtKB/TrEMBL
    E9PU30, Q499T5
    Related
    ENSRNOP00000026323.5, ENSRNOT00000026323.7
    Conserved Domains (4) summary
    smart00720
    Location:687 → 810
    calpain_III; calpain_III domain
    cd00044
    Location:214 → 538
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    cd02681
    Location:5 → 76
    MIT_calpain7_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in the nuclear thiol protease PalBH. The molecular function of the MIT domain is unclear.
    cl00299
    Location:85 → 157
    MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    6552048..6588317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275347.1 → XP_063131417.1  calpain-7 isoform X3

  2. XM_006252608.5 → XP_006252670.2  calpain-7 isoform X1

    See identical proteins and their annotated locations for XP_006252670.2

    Conserved Domains (3) summary
    smart00720
    Location:643 → 766
    calpain_III; calpain_III domain
    cd00044
    Location:170 → 494
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    cl00299
    Location:41 → 113
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...

  3. XM_039094448.2 → XP_038950376.1  calpain-7 isoform X2

    Conserved Domains (2) summary
    smart00720
    Location:522 → 645
    calpain_III; calpain_III domain
    cd00044
    Location:49 → 373
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

  4. XM_039094447.2 → XP_038950375.1  calpain-7 isoform X2

    Conserved Domains (2) summary
    smart00720
    Location:522 → 645
    calpain_III; calpain_III domain
    cd00044
    Location:49 → 373
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

  5. XM_039094450.2 → XP_038950378.1  calpain-7 isoform X2

    Conserved Domains (2) summary
    smart00720
    Location:522 → 645
    calpain_III; calpain_III domain
    cd00044
    Location:49 → 373
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
Nucleotide Protein Strain
Heading Accession and Version

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