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Flnb filamin B [ Rattus norvegicus (Norway rat) ]

Gene ID: 306204, updated on 6-Jul-2026
Symbol
Flnbprovided by RGD
Full Name
filamin Bprovided by RGD
Primary source
RGD:1311915
See related
Ensembl:ENSRNOG00000009470 AllianceGenome:RGD:1311915
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity. Predicted to act upstream of or within several processes, including cellular response to type II interferon; epithelial cell development; and skeletal muscle tissue development. Located in neuronal cell body. Human ortholog(s) of this gene implicated in Larsen syndrome; bone development disease (multiple); cleft palate; and spinal disease (multiple). Orthologous to human FLNB (filamin B). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Kidney (RPKM 310.7), Lung (RPKM 189.4) and 9 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Flnb in Genome Data Viewer
Location:
15p14
Exon count:
46
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (19392212..19525278, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (16961999..17095059, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene deoxyribonuclease 1L3 Neighboring gene uncharacterized LOC103693818 Neighboring gene ATP6V1F neighbor like Neighboring gene uncharacterized LOC134482086 Neighboring gene ribosomal protein S19, pseudogene 15 Neighboring gene POTE ankyrin domain family member H Neighboring gene UTP4 small subunit processome component, pseudogene 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Mutations in the gene encoding filamin B disrupt vertebral segmentation, joint formation and skeletogenesis. Krakow D, et al. Nat Genet, 2004 Apr. PMID 14991055
  2. Mutations in FLNB cause boomerang dysplasia. Bicknell LS, et al. J Med Genet, 2005 Jul. PMID 15994868, Free PMC Article
  3. Mutations in two regions of FLNB result in atelosteogenesis I and III. Farrington-Rock C, et al. Hum Mutat, 2006 Jul. PMID 16752402
  4. A molecular and clinical study of Larsen syndrome caused by mutations in FLNB. Bicknell LS, et al. J Med Genet, 2007 Feb. PMID 16801345, Free PMC Article
  5. Three novel missense mutations in the filamin B gene are associated with isolated congenital talipes equinovarus. Yang H, et al. Hum Genet, 2016 Oct. PMID 27395407

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within epithelial cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within keratinocyte development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in brush border IEA
Inferred from Electronic Annotation
more info
  
located_in brush border ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagocytic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in stress fiber IEA
Inferred from Electronic Annotation
more info
  
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
filamin-B
Names
filamin B, beta
filamin, beta
filamin-B-like

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107288.2 → NP_001100758.1  filamin-B isoform 3

    See identical proteins and their annotated locations for NP_001100758.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A8I6GK95, D4A8D5
    Related
    ENSRNOP00000061198.1, ENSRNOT00000066546.3
    Conserved Domains (3) summary
    smart00557
    Location:1421 → 1514
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00014
    Location:17 → 121
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00630
    Location:1418 → 1508
    Filamin; Filamin/ABP280 repeat

  2. NM_001431546.1 → NP_001418475.1  filamin-B isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A0G2JXT8, A0A8I6GK95

  3. NM_001431547.1 → NP_001418476.1  filamin-B isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A8I6GK95

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    19392212..19525278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251780.5 → XP_006251842.1  

    Related
    ENSRNOP00000070399.1, ENSRNOT00000088264.3
    Conserved Domains (3) summary
    smart00557
    Location:1421 → 1514
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00014
    Location:17 → 121
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00630
    Location:1418 → 1508
    Filamin; Filamin/ABP280 repeat

  2. XM_006251781.5 → XP_006251843.1  

    Conserved Domains (3) summary
    smart00557
    Location:1421 → 1514
    IG_FLMN; Filamin-type immunoglobulin domains
    cd00014
    Location:17 → 121
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00630
    Location:1418 → 1508
    Filamin; Filamin/ABP280 repeat
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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