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Pxk PX domain containing serine/threonine kinase like [ Rattus norvegicus (Norway rat) ]

Gene ID: 306203, updated on 10-Feb-2026
Official Symbol
Pxkprovided by RGD
Official Full Name
PX domain containing serine/threonine kinase likeprovided by RGD
Primary source
RGD:727819
See related
Ensembl:ENSRNOG00000008024 AllianceGenome:RGD:727819
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including ATP binding activity; actin binding activity; and phosphatidylinositol binding activity. Predicted to be involved in several processes, including modulation of chemical synaptic transmission; negative regulation of ATP-dependent activity; and negative regulation of monoatomic ion transport. Predicted to be located in centriolar satellite; cytosol; and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human PXK (PX domain containing serine/threonine kinase like). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Spleen (RPKM 79.5), Kidney (RPKM 78.2) and 9 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See Pxk in Genome Data Viewer
Location:
15p14
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (19190085..19258711, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (16759857..16828452, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (18548209..18616617, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene heat shock protein family E (Hsp10) member 1, pseudogene 2 Neighboring gene pyruvate dehydrogenase E1 subunit beta Neighboring gene ribonuclease P/MRP subunit p14 Neighboring gene abhydrolase domain containing 6, acylglycerol lipase

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Expression pattern and subcellular localization of five splice isoforms of human PXK. Zou X, et al. Int J Mol Med, 2005 Oct. PMID 16142408
  2. MONaKA, a novel modulator of the plasma membrane Na,K-ATPase. Mao H, et al. J Neurosci, 2005 Aug 31. PMID 16135750, Free PMC Article
  3. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN), et al. Nat Genet, 2008 Feb. PMID 18204446, Free PMC Article
  4. A novel family of transmembrane proteins interacting with beta subunits of the Na,K-ATPase. Gorokhova S, et al. Hum Mol Genet, 2007 Oct 15. PMID 17606467
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Clone Names

  • MGC114238

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in modulation of chemical synaptic transmission ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of ATP-dependent activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of monoatomic ion transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
PX domain-containing protein kinase-like protein
Names
MONaKA
PX serine/threonine kinase
modulator of Na,K-ATPase

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399677.1 → NP_001386606.1  PX domain-containing protein kinase-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/Swiss-Prot
    Q4FZZ1, Q7TNZ7
    UniProtKB/TrEMBL
    A0A8I5ZY08
    Related
    ENSRNOP00000010763.6, ENSRNOT00000010763.8

  2. NM_182821.2 → NP_877973.1  PX domain-containing protein kinase-like protein isoform 1

    See identical proteins and their annotated locations for NP_877973.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A140TAA2, A0A8I5ZY08
    Conserved Domains (2) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198 → 345
    PKc; Catalytic domain of Protein Kinases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    19190085..19258711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017599722.2 → XP_017455211.1  PX domain-containing protein kinase-like protein isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZPL8, A0A8I5ZY08
    Related
    ENSRNOP00000079956.2, ENSRNOT00000094093.2

  2. XM_063274363.1 → XP_063130433.1  PX domain-containing protein kinase-like protein isoform X3

    UniProtKB/TrEMBL
    A6K0B8

  3. XM_063274362.1 → XP_063130432.1  PX domain-containing protein kinase-like protein isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZY08
    Related
    ENSRNOP00000084053.1, ENSRNOT00000098948.2

  4. XM_008770539.4 → XP_008768761.1  PX domain-containing protein kinase-like protein isoform X9

    UniProtKB/TrEMBL
    A6K0B8
    Conserved Domains (1) summary
    cd00180
    Location:61 → 208
    PKc; Catalytic domain of Protein Kinases

  5. XM_039093421.2 → XP_038949349.1  PX domain-containing protein kinase-like protein isoform X11

    Conserved Domains (2) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cl21453
    Location:198 → 345
    PKc_like; Protein Kinases, catalytic domain

  6. XM_063274365.1 → XP_063130435.1  PX domain-containing protein kinase-like protein isoform X10

  7. XM_017599727.2 → XP_017455216.1  PX domain-containing protein kinase-like protein isoform X8

  8. XM_017599725.3 → XP_017455214.1  PX domain-containing protein kinase-like protein isoform X6

  9. XM_017599726.3 → XP_017455215.1  PX domain-containing protein kinase-like protein isoform X7

  10. XM_006251776.5 → XP_006251838.1  PX domain-containing protein kinase-like protein isoform X5

    UniProtKB/TrEMBL
    A0A8I6G486
    Related
    ENSRNOP00000080198.1, ENSRNOT00000099957.2
    Conserved Domains (2) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198 → 345
    PKc; Catalytic domain of Protein Kinases

  11. XM_017599723.3 → XP_017455212.1  PX domain-containing protein kinase-like protein isoform X4

RNA

  1. XR_010057833.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4FZZ1.1 GenPept UniProtKB/Swiss-Prot:Q4FZZ1

Gene LinkOut

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