U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

hesx1 HESX homeobox 1 [ Danio rerio (zebrafish) ]

Gene ID: 30620, updated on 8-Dec-2022

Summary

Official Symbol
hesx1provided by ZNC
Official Full Name
HESX homeobox 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-130
See related
Ensembl:ENSDARG00000060734 AllianceGenome:ZFIN:ZDB-GENE-990415-130
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Anf; danf; zanf
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within forebrain development. Predicted to be located in early endosome membrane; phagocytic vesicle; and ruffle. Predicted to be active in nucleus. Is expressed in anterior presumptive neural plate; neural keel; neural plate; and telencephalon. Human ortholog(s) of this gene implicated in septooptic dysplasia. Orthologous to human HESX1 (HESX homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See hesx1 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (42633379..42634720)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (42344033..42345374)
103 previous assembly Zv9 (GCF_000002035.4) 11 NC_007122.5 (43713897..43715238)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box containing 14a Neighboring gene adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 Neighboring gene interleukin 17 receptor D Neighboring gene si:ch73-106k19.2

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within forebrain development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within forebrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in phagocytic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in ruffle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
homeobox expressed in ES cells 1
Names
anf1
anterior neural folds homolog
homeo box (expressed in ES cells) 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131349.1NP_571424.1  homeobox expressed in ES cells 1

    See identical proteins and their annotated locations for NP_571424.1

    Status: PROVISIONAL

    Source sequence(s)
    U65433
    UniProtKB/TrEMBL
    P79738
    Related
    ENSDARP00000071182.6, ENSDART00000076711.7
    Conserved Domains (1) summary
    pfam00046
    Location:83136
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    42633379..42634720
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)