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HCRTR2 hypocretin receptor 2 [ Homo sapiens (human) ]

Gene ID: 3062, updated on 25-Jan-2022

Summary

Official Symbol
HCRTR2provided by HGNC
Official Full Name
hypocretin receptor 2provided by HGNC
Primary source
HGNC:HGNC:4849
See related
Ensembl:ENSG00000137252 MIM:602393; AllianceGenome:HGNC:4849
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OX2R; OXR2; ORXR2
Summary
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See HCRTR2 in Genome Data Viewer
Location:
6p12.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (55106469..55284698)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (54971267..55147415)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986606 Neighboring gene RNA, U6 small nuclear 1023, pseudogene Neighboring gene family with sequence similarity 83 member B Neighboring gene Sharpr-MPRA regulatory region 2673 Neighboring gene GDNF family receptor alpha like Neighboring gene 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1 Neighboring gene Sharpr-MPRA regulatory region 3486

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Common genetic variation and the control of HIV-1 in humans.
EBI GWAS Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neuropeptide receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables orexin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables orexin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptide hormone binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
orexin receptor type 2
Names
hypocretin (orexin) receptor 2
hypocretin receptor type 2
orexin type-2 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012447.2 RefSeqGene

    Range
    5001..181281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001384272.1NP_001371201.1  orexin receptor type 2

    Status: REVIEWED

    Source sequence(s)
    AL449104, AL591718
    Related
    ENSP00000359899.3, ENST00000370862.4
    Conserved Domains (2) summary
    cd15208
    Location:55375
    7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
    pfam03827
    Location:387444
    Orexin_rec2; Orexin receptor type 2
  2. NM_001526.5NP_001517.2  orexin receptor type 2

    See identical proteins and their annotated locations for NP_001517.2

    Status: REVIEWED

    Source sequence(s)
    AL449104, AL591718
    Consensus CDS
    CCDS4956.1
    UniProtKB/Swiss-Prot
    O43614
    UniProtKB/TrEMBL
    S4X0W3
    Related
    ENSP00000477548.1, ENST00000615358.4
    Conserved Domains (2) summary
    cd15208
    Location:55375
    7tmA_OXR; orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
    pfam03827
    Location:387444
    Orexin_rec2; Orexin receptor type 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    55106469..55284698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010798.1XP_016866287.1  orexin receptor type 2 isoform X1

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