Clybl citramalyl-CoA lyase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Clyblprovided by RGD
Official Full Name: citramalyl-CoA lyaseprovided by RGD
Primary source: RGD:1304615
See related: Ensembl:ENSRNOG00000014075 AllianceGenome:RGD:1304615
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable (S)-citramalyl-CoA lyase activity; magnesium ion binding activity; and malate synthase activity. Predicted to be involved in positive regulation of cobalamin metabolic process and protein homotrimerization. Predicted to be located in mitochondrion. Orthologous to human CLYBL (citramalyl-CoA lyase). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Heart (RPKM 191.6), Kidney (RPKM 184.8) and 8 other tissues See more
Orthologs: all
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Genomic context

Location:: 15q25

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (105690283..105912347)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (99283644..99505697)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

BE102058 (e-PCR)
- UniSTS:244056

D15Rat157 (e-PCR)
- UniSTS:226717

d15rat28 (e-PCR)
- UniSTS:121063

RH143957 (e-PCR)
- UniSTS:233203

AI256068 (e-PCR)
- UniSTS:180724

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables (S)-citramalyl-CoA lyase activity	IBA Inferred from Biological aspect of Ancestor more info
enables (S)-citramalyl-CoA lyase activity	IEA Inferred from Electronic Annotation more info
enables (S)-citramalyl-CoA lyase activity	ISO Inferred from Sequence Orthology more info
enables (S)-citramalyl-CoA lyase activity	ISS Inferred from Sequence or Structural Similarity more info
enables acyl-CoA hydrolase activity	IEA Inferred from Electronic Annotation more info
enables acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables malate synthase activity	IEA Inferred from Electronic Annotation more info
enables malate synthase activity	ISO Inferred from Sequence Orthology more info
enables malate synthase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in positive regulation of cobalamin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein homotrimerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotrimerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cobalamin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cobalamin metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of cobalamin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of cobalamin metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in toxic metabolite repair	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: citramalyl-CoA lyase, mitochondrial

Names: (3S)-malyl-CoA thioesterase; beta-methylmalate synthase; citrate lyase beta like; citrate lyase subunit beta-like protein, mitochondrial; malate synthase

NP_001094155.1

EC 2.3.3.9

EC 3.1.2.30

EC 4.1.3.25

XP_063130431.1

EC 2.3.3.9

EC 3.1.2.30

EC 4.1.3.25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.