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Tgds TDP-glucose 4,6-dehydratase [ Rattus norvegicus (Norway rat) ]

Gene ID: 306164, updated on 3-Jun-2026
Official Symbol
Tgdsprovided by RGD
Official Full Name
TDP-glucose 4,6-dehydrataseprovided by RGD
Primary source
RGD:1306544
See related
Ensembl:ENSRNOG00000009661 AllianceGenome:RGD:1306544
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable dTDP-glucose 4,6-dehydratase activity. Predicted to be involved in nucleotide-sugar metabolic process. Human ortholog(s) of this gene implicated in Catel Manzke syndrome. Orthologous to human TGDS (TDP-glucose 4,6-dehydratase). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Kidney (RPKM 96.5), Thymus (RPKM 95.5) and 9 other tissues See more
Orthologs
all
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See Tgds in Genome Data Viewer
Location:
15q24
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (101581765..101602779, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (95175064..95195555, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (103319268..103340239, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482233 Neighboring gene uncharacterized LOC102548945 Neighboring gene transfer RNA phenylalanine (anticodon GAA) 5 Neighboring gene G protein-coupled receptor 180 Neighboring gene uncharacterized LOC134482020

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables UDP-glucose 4,6-dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables UDP-glucose 4,6-dehydratase activity ISO
Inferred from Sequence Orthology
more info
  
enables dTDP-glucose 4,6-dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dTDP-glucose 4,6-dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
NOT enables dTDP-glucose 4,6-dehydratase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydro-lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycosaminoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycosaminoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleotide-sugar metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
dTDP-D-glucose 4,6-dehydratase
NP_001381658.1
XP_063130417.1
XP_063130418.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394729.1 → NP_001381658.1  dTDP-D-glucose 4,6-dehydratase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A0G2JZS4
    Related
    ENSRNOP00000071162.3, ENSRNOT00000088909.3
    Conserved Domains (1) summary
    cd05246
    Location:18 → 336
    dTDP_GD_SDR_e; dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    101581765..101602779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274348.1 → XP_063130418.1  dTDP-D-glucose 4,6-dehydratase isoform X2

  2. XM_063274347.1 → XP_063130417.1  dTDP-D-glucose 4,6-dehydratase isoform X1

RNA

  1. XR_010057832.1 RNA Sequence

  2. XR_010057831.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107286.1: Suppressed sequence

    Description
    NM_001107286.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version

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