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sod1 superoxide dismutase 1, soluble [ Danio rerio (zebrafish) ]

Gene ID: 30553, updated on 24-Nov-2024

Summary

Official Symbol
sod1provided by ZNC
Official Full Name
superoxide dismutase 1, solubleprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-258
See related
Ensembl:ENSDARG00000043848 AllianceGenome:ZFIN:ZDB-GENE-990415-258
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ZSOD; cuzn; Cu/Zn-SOD
Summary
Enables superoxide dismutase activity. Acts upstream of or within several processes, including neuron cellular homeostasis; response to metal ion; and response to methylmercury. Predicted to be located in cytoplasm. Predicted to be active in several cellular components, including cytosol; mitochondrion; and peroxisome. Is expressed in several structures, including blastoderm; cardiovascular system; eye; head mesenchyme; and musculature system. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; artery disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and neurodegenerative disease (multiple). Orthologous to human SOD1 (superoxide dismutase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See sod1 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (25694395..25699429, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (25732682..25737716, complement)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene glutamate receptor, ionotropic, kainate 1a Neighboring gene uncharacterized LOC137496620 Neighboring gene TIAM Rac1 associated GEF 1a Neighboring gene SR-related CTD-associated factor 4a Neighboring gene UDP glucuronosyltransferase 5 family, polypeptide D1

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables antioxidant activity IEA
Inferred from Electronic Annotation
more info
 
enables copper ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables superoxide dismutase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables superoxide dismutase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables superoxide dismutase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
superoxide dismutase [Cu-Zn]
Names
Cu-Zn superoxide dismutase
sod(Cu/Zn)
NP_571369.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131294.1NP_571369.1  superoxide dismutase [Cu-Zn]

    See identical proteins and their annotated locations for NP_571369.1

    Status: PROVISIONAL

    Source sequence(s)
    BC055516
    UniProtKB/Swiss-Prot
    O73872
    UniProtKB/TrEMBL
    B2GRH9
    Related
    ENSDARP00000064375.4, ENSDART00000064376.5
    Conserved Domains (1) summary
    cd00305
    Location:4147
    Cu-Zn_Superoxide_Dismutase; Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    25694395..25699429 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)