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Dok7 docking protein 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305448, updated on 8-Apr-2026
Official Symbol
Dok7provided by RGD
Official Full Name
docking protein 7provided by RGD
Primary source
RGD:1566416
See related
Ensembl:ENSRNOG00000022419 AllianceGenome:RGD:1566416
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1566416
Summary
Predicted to enable phosphatidylinositol binding activity; protein kinase binding activity; and signaling adaptor activity. Predicted to be involved in several processes, including positive regulation of Rac protein signal transduction; positive regulation of protein tyrosine kinase activity; and positive regulation of skeletal muscle acetylcholine-gated channel clustering. Predicted to act upstream of or within positive regulation of protein phosphorylation and receptor clustering. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in neuromuscular junction and postsynaptic membrane. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 10 and fetal akinesia deformation sequence syndrome 3. Orthologous to human DOK7 (docking protein 7). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Muscle (RPKM 44.8), Heart (RPKM 42.2) and 4 other tissues See more
Orthologs
all
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See Dok7 in Genome Data Viewer
Location:
14q21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (79890051..79924081, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (75665444..75699413, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (80925409..80963454, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2 variant 1-like Neighboring gene LDL receptor related protein associated protein 1 Neighboring gene HGF activator Neighboring gene regulator of G-protein signaling 12 Neighboring gene ribosomal protein S17 like 4

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in neuromuscular junction development IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
protein Dok-7
Names
downstream of tyrosine kinase 7

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130062.2 → NP_001123534.2  protein Dok-7 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014

  2. NM_001414957.1 → NP_001401886.1  protein Dok-7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A8I6GLL7
    Related
    ENSRNOP00000096459.2, ENSRNOT00000118992.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    79890051..79924081 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017599206.3 → XP_017454695.1  protein Dok-7 isoform X3

  2. XM_039091973.2 → XP_038947901.1  protein Dok-7 isoform X4

    Conserved Domains (3) summary
    PHA03307
    Location:291 → 449
    PHA03307; transcriptional regulator ICP4; Provisional
    cd13165
    Location:26 → 123
    PTB_DOK7; Downstream of tyrosine kinase 7 phosphotyrosine-binding domain (PTBi)
    cl17171
    Location:6 → 25
    PH-like; Pleckstrin homology-like domain

  3. XM_039091972.2 → XP_038947900.1  protein Dok-7 isoform X2

    UniProtKB/TrEMBL
    A0ABK0LJC2, A6IK09
    Conserved Domains (3) summary
    PHA03307
    Location:339 → 497
    PHA03307; transcriptional regulator ICP4; Provisional
    cd13165
    Location:71 → 171
    PTB_DOK7; Downstream of tyrosine kinase 7 phosphotyrosine-binding domain (PTBi)
    cl17171
    Location:1 → 70
    PH-like; Pleckstrin homology-like domain

  4. XM_017599205.3 → XP_017454694.1  protein Dok-7 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GLL7, D3ZDW9
    Related
    ENSRNOP00000036262.5, ENSRNOT00000035385.6

  5. XM_063273153.1 → XP_063129223.1  protein Dok-7 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZVQ6
    Related
    ENSRNOP00000083030.1, ENSRNOT00000098833.2
Nucleotide Protein Strain
Heading Accession and Version

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