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HCFC1 host cell factor C1 [ Homo sapiens (human) ]

Gene ID: 3054, updated on 4-Nov-2018

Summary

Official Symbol
HCFC1provided by HGNC
Official Full Name
host cell factor C1provided by HGNC
Primary source
HGNC:HGNC:4839
See related
Ensembl:ENSG00000172534 MIM:300019; Vega:OTTHUMG00000024222
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CFF; HCF; HCF1; HFC1; MRX3; VCAF; HCF-1; PPP1R89
Summary
This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 11.5), spleen (RPKM 8.5) and 25 other tissues See more
Orthologs

Genomic context

See HCFC1 in Genome Data Viewer
Location:
Xq28
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (153947556..153972360, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153213008..153237284, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene N(alpha)-acetyltransferase 10, NatA catalytic subunit Neighboring gene renin binding protein Neighboring gene HCFC1 antisense RNA 1 Neighboring gene transmembrane protein 187 Neighboring gene microRNA 3202-1 Neighboring gene microRNA 3202-2 Neighboring gene NFE2L2 motif-containing MPRA enhancer 190/191

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat specifically associates with HCFC1 promoter to downregulate HCFC1 expression in T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
    Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
  • Chromatin organization, organism-specific biosystem (from REACTOME)
    Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
  • Deubiquitination, organism-specific biosystem (from REACTOME)
    Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
  • HATs acetylate histones, organism-specific biosystem (from REACTOME)
    HATs acetylate histones, organism-specific biosystemHistone acetyltransferases (HATs) involved in histone modifications are referred to as A-type or nuclear HATs. They can be grouped into at least four families based on sequence conservation within th...
  • Herpes simplex infection, organism-specific biosystem (from KEGG)
    Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Herpes simplex infection, conserved biosystem (from KEGG)
    Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Mitochondrial Gene Expression, organism-specific biosystem (from WikiPathways)
    Mitochondrial Gene Expression, organism-specific biosystemNumerous nuclear-encoded genes co-ordinate the expression of genes encoded on the mitochondrial genome.
  • Mitochondrial biogenesis, organism-specific biosystem (from REACTOME)
    Mitochondrial biogenesis, organism-specific biosystemMitochondrial biogenesis and remodeling occur in response to exercise and redox state (reviewed in Scarpulla et al. 2012, Handy and Loscalzo 2012, Piantadosi and Suliman 2012, Scarpulla 2011, Wenz et...
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Transcriptional activation of mitochondrial biogenesis, organism-specific biosystem (from REACTOME)
    Transcriptional activation of mitochondrial biogenesis, organism-specific biosystemPhosphorylated PPARGC1A (PGC-1alpha) does not bind DNA directly but instead interacts with other transcription factors, notably NRF1 and NRF2 (via HCF1). NRF1 and NRF2 together with PPARGC1A activate...
  • UCH proteinases, organism-specific biosystem (from REACTOME)
    UCH proteinases, organism-specific biosystemDUBs of the Ub C-terminal Hydrolase (UCH) family are thiol proteases that have an N-terminal catalytic domain sometimes followed by C-terminal extensions that mediate protein-protein interactions. Hu...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC70925

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
histone H4-K16 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H4-K5 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H4-K8 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion organization TAS
Traceable Author Statement
more info
 
negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell cycle TAS
Traceable Author Statement
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
release from viral latency NAS
Non-traceable Author Statement
more info
PubMed 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with Ada2/Gcn5/Ada3 transcription activator complex IDA
Inferred from Direct Assay
more info
PubMed 
MLL1 complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with SAGA-type complex IDA
Inferred from Direct Assay
more info
PubMed 
Set1C/COMPASS complex IDA
Inferred from Direct Assay
more info
PubMed 
axon IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IEA
Inferred from Electronic Annotation
more info
 
histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
host cell factor 1
Names
VP16-accessory protein
protein phosphatase 1, regulatory subunit 89

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012513.1 RefSeqGene

    Range
    5001..28812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005334.2NP_005325.2  host cell factor 1

    See identical proteins and their annotated locations for NP_005325.2

    Status: REVIEWED

    Source sequence(s)
    BC010606, BC063435, L20010
    Consensus CDS
    CCDS44020.1
    UniProtKB/Swiss-Prot
    P51610
    Related
    ENSP00000309555.7, OTTHUMP00000025995, ENST00000310441.11, OTTHUMT00000061099
    Conserved Domains (6) summary
    PLN02153
    Location:12330
    PLN02153; epithiospecifier protein
    cd00063
    Location:18561885
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    sd00038
    Location:200253
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:3269
    Kelch_1; Kelch motif
    pfam13415
    Location:215263
    Kelch_3; Galactose oxidase, central domain
    pfam13854
    Location:134179
    Kelch_5; Kelch motif

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    153947556..153972360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029471.2XP_016884960.1  host cell factor 1 isoform X5

  2. XM_011531147.3XP_011529449.1  host cell factor 1 isoform X3

    Conserved Domains (6) summary
    PLN02153
    Location:12330
    PLN02153; epithiospecifier protein
    cd00063
    Location:18601889
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    sd00038
    Location:200253
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:3269
    Kelch_1; Kelch motif
    pfam13415
    Location:215263
    Kelch_3; Galactose oxidase, central domain
    pfam13854
    Location:134179
    Kelch_5; Kelch motif
  3. XM_006724815.3XP_006724878.1  host cell factor 1 isoform X1

    UniProtKB/TrEMBL
    A6NEM2
    Related
    ENSP00000359001.4, OTTHUMP00000025997, ENST00000369984.4
    Conserved Domains (6) summary
    PLN02153
    Location:12330
    PLN02153; epithiospecifier protein
    cd00063
    Location:19011930
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    sd00038
    Location:200253
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:3269
    Kelch_1; Kelch motif
    pfam13415
    Location:215263
    Kelch_3; Galactose oxidase, central domain
    pfam13854
    Location:134179
    Kelch_5; Kelch motif
  4. XM_011531148.3XP_011529450.1  host cell factor 1 isoform X4

    Conserved Domains (6) summary
    PLN02153
    Location:12330
    PLN02153; epithiospecifier protein
    cd00063
    Location:18591888
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    sd00038
    Location:200253
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:3269
    Kelch_1; Kelch motif
    pfam13415
    Location:215263
    Kelch_3; Galactose oxidase, central domain
    pfam13854
    Location:134179
    Kelch_5; Kelch motif
  5. XM_006724816.3XP_006724879.1  host cell factor 1 isoform X2

    UniProtKB/Swiss-Prot
    P51610
    Conserved Domains (6) summary
    PLN02153
    Location:12330
    PLN02153; epithiospecifier protein
    cd00063
    Location:19001929
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    sd00038
    Location:200253
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:3269
    Kelch_1; Kelch motif
    pfam13415
    Location:215263
    Kelch_3; Galactose oxidase, central domain
    pfam13854
    Location:134179
    Kelch_5; Kelch motif
  6. XM_017029472.1XP_016884961.1  host cell factor 1 isoform X6

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