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Cdkl2 cyclin dependent kinase like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305242, updated on 5-Aug-2018

Summary

Official Symbol
Cdkl2provided by RGD
Official Full Name
cyclin dependent kinase like 2provided by RGD
Primary source
RGD:1309625
See related
Ensembl:ENSRNOG00000002506
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Brain (RPKM 93.9), Testes (RPKM 42.5) and 7 other tissues See more
Orthologs

Genomic context

See Cdkl2 in Genome Data Viewer
Location:
14p22
Exon count:
16
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (17530170..17565950)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 14 NC_005113.3 (17448431..17483326)

Chromosome 14 - NC_005113.4Genomic Context describing neighboring genes Neighboring gene USO1 vesicle transport factor Neighboring gene G3BP stress granule assembly factor 2 Neighboring gene ragulator complex protein LAMTOR2 pseudogene Neighboring gene protein transport protein Sec61 subunit gamma-like Neighboring gene odontogenesis associated phosphoprotein Neighboring gene THAP domain containing 6 Neighboring gene ring finger and CHY zinc finger domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centrosome IEA
Inferred from Electronic Annotation
more info
 
centrosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cyclin-dependent kinase-like 2
Names
cyclin-dependent kinase-like 2 (CDC2-related kinase)
NP_001012035.1
XP_006250799.1
XP_006250800.1
XP_006250801.1
XP_006250802.1
XP_006250803.1
XP_008768250.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012035.1NP_001012035.1  cyclin-dependent kinase-like 2

    See identical proteins and their annotated locations for NP_001012035.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083590
    UniProtKB/Swiss-Prot
    Q5XIT0
    Related
    ENSRNOP00000049130.3, ENSRNOT00000050038.4
    Conserved Domains (2) summary
    smart00220
    Location:4289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07846
    Location:2289
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005113.4 Reference Rnor_6.0 Primary Assembly

    Range
    17530170..17565950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008770028.2XP_008768250.1  cyclin-dependent kinase-like 2 isoform X1

    See identical proteins and their annotated locations for XP_008768250.1

    UniProtKB/TrEMBL
    A0A0G2K4K8
    Conserved Domains (2) summary
    smart00220
    Location:4289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07846
    Location:2289
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
  2. XM_006250739.3XP_006250801.1  cyclin-dependent kinase-like 2 isoform X1

    See identical proteins and their annotated locations for XP_006250801.1

    UniProtKB/TrEMBL
    A0A0G2K4K8
    Conserved Domains (2) summary
    smart00220
    Location:4289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07846
    Location:2289
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
  3. XM_006250740.3XP_006250802.1  cyclin-dependent kinase-like 2 isoform X1

    See identical proteins and their annotated locations for XP_006250802.1

    UniProtKB/TrEMBL
    A0A0G2K4K8
    Conserved Domains (2) summary
    smart00220
    Location:4289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07846
    Location:2289
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
  4. XM_006250741.3XP_006250803.1  cyclin-dependent kinase-like 2 isoform X1

    See identical proteins and their annotated locations for XP_006250803.1

    UniProtKB/TrEMBL
    A0A0G2K4K8
    Conserved Domains (2) summary
    smart00220
    Location:4289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07846
    Location:2289
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
  5. XM_006250738.3XP_006250800.1  cyclin-dependent kinase-like 2 isoform X1

    See identical proteins and their annotated locations for XP_006250800.1

    UniProtKB/TrEMBL
    A0A0G2K4K8
    Conserved Domains (2) summary
    smart00220
    Location:4289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07846
    Location:2289
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
  6. XM_006250737.3XP_006250799.1  cyclin-dependent kinase-like 2 isoform X1

    See identical proteins and their annotated locations for XP_006250799.1

    UniProtKB/TrEMBL
    A0A0G2K4K8
    Related
    ENSRNOP00000073081.1, ENSRNOT00000079304.1
    Conserved Domains (2) summary
    smart00220
    Location:4289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07846
    Location:2289
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

Alternate Rn_Celera

Genomic

  1. AC_000082.1 Alternate Rn_Celera

    Range
    15421440..15444142
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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