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Zfp644 zinc finger protein 644 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305127, updated on 11-Apr-2024

Summary

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Symbol
Zfp644provided by RGD
Full Name
zinc finger protein 644provided by RGD
Primary source
RGD:1306805
See related
Ensembl:ENSRNOG00000002112 AllianceGenome:RGD:1306805
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Znf644; RGD1306805
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription corepressor binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in myopia. Orthologous to human ZNF644 (zinc finger protein 644). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 125.7), Brain (RPKM 106.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
14p22
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (3248350..3324820)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (3105002..3179961)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (4125368..4200332)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene uncharacterized LOC120096554 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene keratin-associated protein 10-6-like Neighboring gene basic salivary proline-rich protein 2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 644

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001139484.3 → NP_001132956.1  zinc finger protein 644

    See identical proteins and their annotated locations for NP_001132956.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A6KPL0, D4A778
    Conserved Domains (3) summary
    sd00017
    Location:498 → 518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:412 → 432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:448 → 470
    zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    3248350..3324820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017599151.3 → XP_017454640.2  zinc finger protein 644 isoform X1

  2. XM_063273040.1 → XP_063129110.1  zinc finger protein 644 isoform X3

  3. XM_063273042.1 → XP_063129112.1  zinc finger protein 644 isoform X6

  4. XM_039091807.2 → XP_038947735.1  zinc finger protein 644 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A0C1, D4A778
    Conserved Domains (3) summary
    sd00017
    Location:473 → 493
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:387 → 407
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:423 → 445
    zf-C2H2; Zinc finger, C2H2 type

  5. XM_006250550.3 → XP_006250612.1  zinc finger protein 644 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A9B0, D4A778
    Related
    ENSRNOP00000087711.1
    Conserved Domains (3) summary
    sd00017
    Location:516 → 536
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:430 → 450
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl19114
    Location:456 → 519
    RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain

  6. XM_063273038.1 → XP_063129108.1  zinc finger protein 644 isoform X1

  7. XM_063273037.1 → XP_063129107.1  zinc finger protein 644 isoform X1

  8. XM_063273043.1 → XP_063129113.1  zinc finger protein 644 isoform X7

  9. XM_006250554.5 → XP_006250616.1  zinc finger protein 644 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A0C1, D4A778
    Related
    ENSRNOP00000085517.1
    Conserved Domains (3) summary
    sd00017
    Location:473 → 493
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:387 → 407
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:423 → 445
    zf-C2H2; Zinc finger, C2H2 type

  10. XM_063273041.1 → XP_063129111.1  zinc finger protein 644 isoform X5

  11. XM_063273039.1 → XP_063129109.1  zinc finger protein 644 isoform X1

RNA

  1. XR_010057362.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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