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Nuf2 NUF2 component of NDC80 kinetochore complex [ Rattus norvegicus (Norway rat) ]

Gene ID: 304951, updated on 5-Jan-2022

Summary

Official Symbol
Nuf2provided by RGD
Official Full Name
NUF2 component of NDC80 kinetochore complexprovided by RGD
Primary source
RGD:1307952
See related
Ensembl:ENSRNOG00000002711
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cdca1
Summary
Predicted to be involved in kinetochore organization; mitotic spindle organization; and nuclear division. Predicted to be located in cytosol; kinetochore; and nucleoplasm. Predicted to be part of Ndc80 complex. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma and pancreatic cancer. Orthologous to human NUF2 (NUF2 component of NDC80 kinetochore complex). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Thymus (RPKM 181.1), Spleen (RPKM 85.4) and 8 other tissues See more
Orthologs
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Genomic context

See Nuf2 in Genome Data Viewer
Location:
13q24
Exon count:
14
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (81693675..81722765, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (87818456..87847223, complement)

Chromosome 13 - NC_051348.1Genomic Context describing neighboring genes Neighboring gene similar to 60S ribosomal protein L7 Neighboring gene uncharacterized LOC103692065 Neighboring gene translocase of inner mitochondrial membrane 23 (yeast) homolog Neighboring gene regulator of G-protein signaling 5

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-containing complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in attachment of spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in kinetochore organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in meiotic chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of Ndc80 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Ndc80 complex ISO
Inferred from Sequence Orthology
more info
 
part_of Ndc80 complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
kinetochore protein Nuf2
Names
NDC80 kinetochore complex component NUF2
NUF2, NDC80 kinetochore complex component, homolog
cell division cycle associated 1
cell division cycle-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012028.1NP_001012028.1  kinetochore protein Nuf2

    See identical proteins and their annotated locations for NP_001012028.1

    Status: PROVISIONAL

    Source sequence(s)
    BC078993
    UniProtKB/Swiss-Prot
    Q6AYL9
    Related
    ENSRNOP00000003650.5, ENSRNOT00000003650.7
    Conserved Domains (2) summary
    COG1340
    Location:175443
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    pfam03800
    Location:3146
    Nuf2; Nuf2 family

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051348.1 Reference mRatBN7.2 Primary Assembly

    Range
    81693675..81722765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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