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Zbtb37 zinc finger and BTB domain containing 37 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304918, updated on 7-Apr-2025

Summary

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Official Symbol
Zbtb37provided by RGD
Official Full Name
zinc finger and BTB domain containing 37provided by RGD
Primary source
RGD:1308731
See related
EnsemblRapid:ENSRNOG00000026907 AllianceGenome:RGD:1308731
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308731
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. Orthologous to human ZBTB37 (zinc finger and BTB domain containing 37). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Lung (RPKM 80.3), Kidney (RPKM 73.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zbtb37 in Genome Data Viewer
Location:
13q22
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (75805272..75836702, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (73271920..73303427, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (78836491..78852224, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene ring finger and CCCH-type domains 1 Neighboring gene bolA family member 2 like 2 Neighboring gene serpin family C member 1 Neighboring gene small nucleolar RNA SNORD74 Neighboring gene small nucleolar RNA SNORD75 Neighboring gene growth arrest specific 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107191.1 → NP_001100661.1  zinc finger and BTB domain-containing protein 37

    See identical proteins and their annotated locations for NP_001100661.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473958
    UniProtKB/TrEMBL
    A6ID69, D3ZGJ3
    Related
    ENSRNOP00000068362.1, ENSRNOT00000076514.4
    Conserved Domains (5) summary
    sd00017
    Location:377 → 397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18222
    Location:9 → 131
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
    pfam00096
    Location:403 → 425
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:418 → 440
    zf-H2C2_2; Zinc-finger double domain
    pfam15961
    Location:429 → 497
    DUF4764; Domain of unknown function (DUF4764)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    75805272..75836702 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090780.2 → XP_038946708.1  zinc finger and BTB domain-containing protein 37 isoform X2

    UniProtKB/TrEMBL
    A0A096MKF3
    Conserved Domains (1) summary
    cd18222
    Location:9 → 131
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)

  2. XM_063272356.1 → XP_063128426.1  zinc finger and BTB domain-containing protein 37 isoform X2

    UniProtKB/TrEMBL
    A0A096MKF3
    Related
    ENSRNOP00000068493.2, ENSRNOT00000076985.4

  3. XM_039090779.2 → XP_038946707.1  zinc finger and BTB domain-containing protein 37 isoform X1

    UniProtKB/TrEMBL
    A6ID69, D3ZGJ3
    Conserved Domains (5) summary
    sd00017
    Location:377 → 397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18222
    Location:9 → 131
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
    pfam00096
    Location:403 → 425
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:418 → 440
    zf-H2C2_2; Zinc-finger double domain
    pfam15961
    Location:429 → 497
    DUF4764; Domain of unknown function (DUF4764)

  4. XM_006250110.5 → XP_006250172.1  zinc finger and BTB domain-containing protein 37 isoform X1

    See identical proteins and their annotated locations for XP_006250172.1

    UniProtKB/TrEMBL
    A6ID69, D3ZGJ3
    Conserved Domains (5) summary
    sd00017
    Location:377 → 397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18222
    Location:9 → 131
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
    pfam00096
    Location:403 → 425
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:418 → 440
    zf-H2C2_2; Zinc-finger double domain
    pfam15961
    Location:429 → 497
    DUF4764; Domain of unknown function (DUF4764)

  5. XM_063272357.1 → XP_063128427.1  zinc finger and BTB domain-containing protein 37 isoform X2

    UniProtKB/TrEMBL
    A0A096MKF3

  6. XM_006250111.5 → XP_006250173.1  zinc finger and BTB domain-containing protein 37 isoform X1

    See identical proteins and their annotated locations for XP_006250173.1

    UniProtKB/TrEMBL
    A6ID69, D3ZGJ3
    Conserved Domains (5) summary
    sd00017
    Location:377 → 397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18222
    Location:9 → 131
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
    pfam00096
    Location:403 → 425
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:418 → 440
    zf-H2C2_2; Zinc-finger double domain
    pfam15961
    Location:429 → 497
    DUF4764; Domain of unknown function (DUF4764)

RNA

  1. XR_005492247.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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