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Rabgap1l RAB GTPase activating protein 1-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 304914, updated on 3-Jun-2026
Official Symbol
Rabgap1lprovided by RGD
Official Full Name
RAB GTPase activating protein 1-likeprovided by RGD
Primary source
RGD:1304620
See related
Ensembl:ENSRNOG00000002736 AllianceGenome:RGD:1304620
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1304620
Summary
Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in regulation of protein localization. Predicted to be located in several cellular components, including Golgi apparatus; cilium; and early endosome. Orthologous to human RABGAP1L (RAB GTPase activating protein 1 like). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Brain (RPKM 85.3), Spleen (RPKM 76.5) and 9 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Rabgap1l in Genome Data Viewer
Location:
13q22
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (74997542..75593240, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (72464114..73059845, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (77975392..78609009, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481579 Neighboring gene calcyclin binding protein Neighboring gene small nucleolar RNA SNORA67 Neighboring gene PHD finger-like domain-containing protein 5A Neighboring gene G protein-coupled receptor 52 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ribosomal protein L7-like 1, pseudogene 1 Neighboring gene large ribosomal subunit protein eL21-like

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. Itoh T, et al. Genes Cells, 2006 Sep. PMID 16923123
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
NOT involved_in regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
rab GTPase-activating protein 1-like

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107190.1 → NP_001100660.1  rab GTPase-activating protein 1-like isoform 2

    See identical proteins and their annotated locations for NP_001100660.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473958
    UniProtKB/TrEMBL
    A0A0G2KAV2, A6ID63, D3ZKH6
    Related
    ENSRNOP00000075539.3, ENSRNOT00000087506.3
    Conserved Domains (3) summary
    cd01211
    Location:129 → 257
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam00566
    Location:541 → 744
    RabGAP-TBC; Rab-GTPase-TBC domain
    pfam12473
    Location:340 → 421
    DUF3694; Kinesin protein

  2. NM_001401442.2 → NP_001388371.1  rab GTPase-activating protein 1-like isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A8I6AXS5
    Related
    ENSRNOP00000093938.2, ENSRNOT00000076272.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    74997542..75593240 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250105.5 → XP_006250167.1  rab GTPase-activating protein 1-like isoform X3

    See identical proteins and their annotated locations for XP_006250167.1

    UniProtKB/TrEMBL
    A0A8I6AXS5
    Conserved Domains (3) summary
    cd01211
    Location:129 → 257
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam00566
    Location:541 → 744
    RabGAP-TBC; Rab-GTPase-TBC domain
    pfam12473
    Location:340 → 421
    DUF3694; Kinesin protein

  2. XM_006250106.5 → XP_006250168.1  rab GTPase-activating protein 1-like isoform X3

    See identical proteins and their annotated locations for XP_006250168.1

    UniProtKB/TrEMBL
    A0A8I6AXS5
    Conserved Domains (3) summary
    cd01211
    Location:129 → 257
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam00566
    Location:541 → 744
    RabGAP-TBC; Rab-GTPase-TBC domain
    pfam12473
    Location:340 → 421
    DUF3694; Kinesin protein

  3. XM_063272349.1 → XP_063128419.1  rab GTPase-activating protein 1-like isoform X1

  4. XM_063272350.1 → XP_063128420.1  rab GTPase-activating protein 1-like isoform X2

  5. XM_039090774.1 → XP_038946702.1  rab GTPase-activating protein 1-like isoform X8

    Conserved Domains (3) summary
    COG1196
    Location:461 → 666
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00566
    Location:188 → 391
    RabGAP-TBC; Rab-GTPase-TBC domain
    pfam12473
    Location:3 → 68
    DUF3694; Kinesin protein

  6. XM_039090773.2 → XP_038946701.1  rab GTPase-activating protein 1-like isoform X7

    Conserved Domains (3) summary
    COG1196
    Location:482 → 687
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00566
    Location:209 → 412
    RabGAP-TBC; Rab-GTPase-TBC domain
    pfam12473
    Location:7 → 89
    DUF3694; Kinesin protein

  7. XM_006250108.4 → XP_006250170.1  rab GTPase-activating protein 1-like isoform X9

    UniProtKB/TrEMBL
    A0A8I6GAC9, A0ABK0LZ58
    Related
    ENSRNOP00000083125.1, ENSRNOT00000076902.3
    Conserved Domains (1) summary
    TIGR01843
    Location:155 → 323
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family

  8. XM_039090778.2 → XP_038946706.1  rab GTPase-activating protein 1-like isoform X11

    UniProtKB/TrEMBL
    A0ABK0LRE9

  9. XM_008769644.4 → XP_008767866.1  rab GTPase-activating protein 1-like isoform X10

    See identical proteins and their annotated locations for XP_008767866.1

    UniProtKB/TrEMBL
    A0ABK0M092
    Conserved Domains (1) summary
    COG1196
    Location:68 → 276
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  10. XM_039090777.2 → XP_038946705.1  rab GTPase-activating protein 1-like isoform X10

    UniProtKB/TrEMBL
    A0ABK0M092
    Conserved Domains (1) summary
    COG1196
    Location:68 → 276
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  11. XM_008769643.4 → XP_008767865.1  rab GTPase-activating protein 1-like isoform X10

    See identical proteins and their annotated locations for XP_008767865.1

    UniProtKB/TrEMBL
    A0ABK0M092
    Conserved Domains (1) summary
    COG1196
    Location:68 → 276
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  12. XM_017598819.3 → XP_017454308.1  rab GTPase-activating protein 1-like isoform X10

    UniProtKB/TrEMBL
    A0ABK0M092
    Related
    ENSRNOP00000109416.1, ENSRNOT00000126092.1
    Conserved Domains (1) summary
    COG1196
    Location:68 → 276
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  13. XM_008769645.4 → XP_008767867.1  rab GTPase-activating protein 1-like isoform X12

    See identical proteins and their annotated locations for XP_008767867.1

    UniProtKB/TrEMBL
    A0ABK0LRE9
    Related
    ENSRNOP00000108648.1, ENSRNOT00000114691.2
    Conserved Domains (1) summary
    TIGR01843
    Location:38 → 206
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family

  14. XM_006250107.5 → XP_006250169.1  rab GTPase-activating protein 1-like isoform X4

    See identical proteins and their annotated locations for XP_006250169.1

    UniProtKB/TrEMBL
    A0A0G2KAV2, A6ID63, D3ZKH6
    Conserved Domains (3) summary
    cd01211
    Location:129 → 257
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam00566
    Location:541 → 744
    RabGAP-TBC; Rab-GTPase-TBC domain
    pfam12473
    Location:340 → 421
    DUF3694; Kinesin protein

  15. XM_063272353.1 → XP_063128423.1  rab GTPase-activating protein 1-like isoform X13

  16. XM_063272355.1 → XP_063128425.1  rab GTPase-activating protein 1-like isoform X14

  17. XM_063272354.1 → XP_063128424.1  rab GTPase-activating protein 1-like isoform X14

  18. XM_063272352.1 → XP_063128422.1  rab GTPase-activating protein 1-like isoform X6

    UniProtKB/TrEMBL
    A0A8I6A1M6, D3ZKH6
    Related
    ENSRNOP00000084608.2, ENSRNOT00000076999.4

  19. XM_063272351.1 → XP_063128421.1  rab GTPase-activating protein 1-like isoform X5

    UniProtKB/TrEMBL
    A0A8I6G9C0
Nucleotide Protein Strain
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