Morc3 MORC family CW-type zinc finger 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Morc3provided by RGD
Official Full Name: MORC family CW-type zinc finger 3provided by RGD
Primary source: RGD:1307924
See related: Ensembl:ENSRNOG00000026236 AllianceGenome:RGD:1307924
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Zcwcc3
Summary: Predicted to enable DNA binding activity; methylated histone binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in antiviral innate immune response; negative regulation of interferon-beta production; and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including maintenance of protein location in nucleus; positive regulation of cellular senescence; and protein stabilization. Predicted to be located in nucleoplasm. Predicted to be active in PML body and chromatin. Orthologous to human MORC3 (MORC family CW-type zinc finger 3). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Biased expression in Thymus (RPKM 269.2), Spleen (RPKM 247.5) and 9 other tissues See more
Orthologs: all
: Try the new Gene page
Try the new Transcripts and proteins table

Genomic context

Location:: 11q11

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (46621575..46664315)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (33151906..33194650)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

BE111888 (e-PCR)
- UniSTS:245801

BF404482 (e-PCR)
- UniSTS:247110

AI452146 (e-PCR)
- UniSTS:160598

RH139194 (e-PCR)
- UniSTS:221280

1110051N18Rik (e-PCR), detects polymorphism
- UniSTS:259014

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables histone H3K4me3 reader activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K4me3 reader activity	IEA Inferred from Electronic Annotation more info
enables histone H3K4me3 reader activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antiviral innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in antiviral innate immune response	IEA Inferred from Electronic Annotation more info
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within maintenance of protein location in nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interferon-beta production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cellular senescence	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein stabilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in PML body	IBA Inferred from Biological aspect of Ancestor more info
located_in PML body	IEA Inferred from Electronic Annotation more info
is_active_in PML body	ISO Inferred from Sequence Orthology more info
located_in PML body	ISO Inferred from Sequence Orthology more info
is_active_in chromatin	IEA Inferred from Electronic Annotation more info
is_active_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: MORC family CW-type zinc finger protein 3

Names: microrchidia 3; zinc finger, CW-type with coiled-coil domain 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395628.1 → NP_001382557.1 MORC family CW-type zinc finger protein 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A0A096MIX0

Conserved Domains (4) summary

TIGR00606
Location:697 → 872

rad50

cd16931
Location:18 → 135

HATPase_MORC-like; Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains

pfam07496
Location:409 → 446

zf-CW; CW-type Zinc Finger

pfam17942
Location:249 → 382

Morc6_S5; Morc6 ribosomal protein S5 domain 2-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

46621575..46664315

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063270588.1 → XP_063126658.1 MORC family CW-type zinc finger protein 3 isoform X5
XM_063270584.1 → XP_063126654.1 MORC family CW-type zinc finger protein 3 isoform X1

UniProtKB/TrEMBL

A0A096MIX0

Related

ENSRNOP00000067908.3, ENSRNOT00000076473.4
XM_063270586.1 → XP_063126656.1 MORC family CW-type zinc finger protein 3 isoform X2
XM_063270585.1 → XP_063126655.1 MORC family CW-type zinc finger protein 3 isoform X2
XM_039088413.2 → XP_038944341.1 MORC family CW-type zinc finger protein 3 isoform X3

Conserved Domains (3) summary

TIGR00606
Location:509 → 684

rad50

pfam07496
Location:221 → 258

zf-CW; CW-type Zinc Finger

pfam17942
Location:61 → 194

Morc6_S5; Morc6 ribosomal protein S5 domain 2-like
XM_039088414.2 → XP_038944342.1 MORC family CW-type zinc finger protein 3 isoform X3

Conserved Domains (3) summary

TIGR00606
Location:509 → 684

rad50

pfam07496
Location:221 → 258

zf-CW; CW-type Zinc Finger

pfam17942
Location:61 → 194

Morc6_S5; Morc6 ribosomal protein S5 domain 2-like
XM_039088415.2 → XP_038944343.1 MORC family CW-type zinc finger protein 3 isoform X4

Conserved Domains (3) summary

TIGR00606
Location:434 → 609

rad50

pfam07496
Location:146 → 183

zf-CW; CW-type Zinc Finger

pfam17942
Location:1 → 119

Morc6_S5; Morc6 ribosomal protein S5 domain 2-like

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001107109.1: Suppressed sequence

Description

NM_001107109.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.