Fam3b FAM3 metabolism regulating signaling molecule B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fam3bprovided by RGD
Official Full Name: FAM3 metabolism regulating signaling molecule Bprovided by RGD
Primary source: RGD:1311662
See related: Ensembl:ENSRNOG00000001962 AllianceGenome:RGD:1311662
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311662
Summary: Predicted to enable carbohydrate binding activity. Predicted to be involved in insulin secretion. Predicted to be located in membrane. Predicted to be active in extracellular space. Orthologous to human FAM3B (FAM3 metabolism regulating signaling molecule B). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Biased expression in Lung (RPKM 64.8), Uterus (RPKM 41.7) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (50300926..50333296, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (36831532..36863902, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (37922308..37993279, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that family with sequence similarity 3, member B protein (FAM3B) inhibited miR-322-5p expression, and enforced expression of miR-322-5p antagonized FAM3B-induced vascular smooth muscle cells (VSMCs) proliferation and migration.
Title: FAM3B mediates high glucose-induced vascular smooth muscle cell proliferation and migration via inhibition of miR-322-5p.

Submit: New GeneRIF Correction

General gene information

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Markers

ORF9 (e-PCR), detects polymorphism
- UniSTS:259644

RH134651 (e-PCR)
- UniSTS:217930

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in insulin secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in insulin secretion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein FAM3B

Names: cytokine-like protein 2-21; family with sequence similarity 3, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107102.2 → NP_001100572.2 protein FAM3B

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A0A096MJ41, D4A1V2

Related

ENSRNOP00000002683.6, ENSRNOT00000002683.8

Conserved Domains (1) summary

cd13939
Location:59 → 233

PANDER_FAM3B; Pancreatic derived factor