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Cep97 centrosomal protein 97 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304007, updated on 3-Apr-2024

Summary

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Official Symbol
Cep97provided by RGD
Official Full Name
centrosomal protein 97provided by RGD
Primary source
RGD:1307400
See related
Ensembl:ENSRNOG00000001609 AllianceGenome:RGD:1307400
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lrriq2; RGD1307400
Summary
Predicted to be involved in negative regulation of cilium assembly and regulation of mitotic spindle assembly. Predicted to be located in centriolar satellite and cytosol. Predicted to be part of protein-containing complex. Orthologous to human CEP97 (centrosomal protein 97). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 69.1), Brain (RPKM 43.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
11q12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (58152561..58187174)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (44683503..44711471)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (47146409..47174460)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 11 Neighboring gene zinc finger and BTB domain containing 11, opposite strand 1 Neighboring gene ribosomal protein L24 Neighboring gene uncharacterized LOC134481067 Neighboring gene neurexophilin and PC-esterase domain family, member 3 Neighboring gene adaptor related protein complex 3 subunit sigma 1, pseudogene 1 Neighboring gene NFKB inhibitor zeta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cep97 and CP110 suppress a cilia assembly program. Spektor A, et al. Cell, 2007 Aug 24. PMID 17719545
  2. The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly. Kobayashi T, et al. J Cell Biol, 2014 Jan 20. PMID 24421332, Free PMC Article
  3. D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone. Popiolek M, et al. J Biol Chem, 2011 Aug 19. PMID 21700703, Free PMC Article
  4. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in negative regulation of cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
centrosomal protein of 97 kDa
Names
centrosomal protein 97kDa
leucine-rich repeats and IQ motif containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107096.1 → NP_001100566.1  centrosomal protein of 97 kDa

    See identical proteins and their annotated locations for NP_001100566.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473967
    UniProtKB/TrEMBL
    A6IQR0, D4AC95
    Related
    ENSRNOP00000002191.2, ENSRNOT00000002191.5
    Conserved Domains (5) summary
    cd00116
    Location:21 → 126
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam14580
    Location:107 → 255
    LRR_9; Leucine-rich repeat
    sd00033
    Location:17 → 37
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:103 → 143
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:80 → 136
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    58152561..58187174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088372.2 → XP_038944300.1  centrosomal protein of 97 kDa isoform X3

    Conserved Domains (2) summary
    sd00033
    Location:17 → 37
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:18 → 242
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  2. XM_039088373.2 → XP_038944301.1  centrosomal protein of 97 kDa isoform X4

    Conserved Domains (2) summary
    sd00033
    Location:17 → 37
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:18 → 242
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  3. XM_063270561.1 → XP_063126631.1  centrosomal protein of 97 kDa isoform X1

    UniProtKB/TrEMBL
    A6IQR3

  4. XM_006248250.4 → XP_006248312.1  centrosomal protein of 97 kDa isoform X2

    Conserved Domains (2) summary
    pfam14580
    Location:19 → 145
    LRR_9; Leucine-rich repeat
    sd00031
    Location:16 → 61
    LRR_1; leucine-rich repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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