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Gtf2e1 general transcription factor IIE subunit 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303918, updated on 15-May-2025
Official Symbol
Gtf2e1provided by RGD
Official Full Name
general transcription factor IIE subunit 1provided by RGD
Primary source
RGD:1306851
See related
Ensembl:ENSRNOG00000026008 AllianceGenome:RGD:1306851
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA polymerase II general transcription initiation factor activity. Predicted to be involved in transcription initiation at RNA polymerase II promoter. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of transcription factor TFIID complex and transcription factor TFIIE complex. Orthologous to human GTF2E1 (general transcription factor IIE subunit 1). [provided by Alliance of Genome Resources, May 2025]
Expression
Biased expression in Thymus (RPKM 46.1), Kidney (RPKM 40.7) and 9 other tissues See more
Orthologs
human mouse all
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See Gtf2e1 in Genome Data Viewer
Location:
11q21
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (76687382..76720253)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (63182073..63215349)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (66078786..66111394)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene keratin, type II cytoskeletal 8-like Neighboring gene homogentisate 1, 2-dioxygenase Neighboring gene RAB, member of RAS oncogene family-like 3 Neighboring gene U2 spliceosomal RNA Neighboring gene syntaxin binding protein 5L Neighboring gene ring finger protein 138, pseudogene 4 Neighboring gene DNA polymerase theta

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Structural insights into transcription initiation by RNA polymerase II. Grünberg S, et al. Trends Biochem Sci, 2013 Dec. PMID 24120742, Free PMC Article
  2. Oestrogen receptor facilitates the formation of preinitiation complex assembly: involvement of the general transcription factor TFIIB. Sabbah M, et al. Biochem J, 1998 Dec 15. PMID 9841876, Free PMC Article
  3. Near-atomic resolution visualization of human transcription promoter opening. He Y, et al. Nature, 2016 May 19. PMID 27193682, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIIE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
general transcription factor IIE subunit 1
Names
general transcription factor IIE, polypeptide 1 (alpha subunit)
general transcription factor IIE, polypeptide 1, alpha

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100556.1 → NP_001094026.1  general transcription factor IIE subunit 1

    See identical proteins and their annotated locations for NP_001094026.1

    Status: VALIDATED

    Source sequence(s)
    BC099237, CA509437, DY311373
    UniProtKB/TrEMBL
    A6IR94, G3V992
    Related
    ENSRNOP00000039601.3, ENSRNOT00000042864.6
    Conserved Domains (2) summary
    smart00531
    Location:28 → 175
    TFIIE; Transcription initiation factor IIE
    pfam11521
    Location:393 → 438
    TFIIE-A_C; C-terminal general transcription factor TFIIE alpha

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    76687382..76720253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088355.2 → XP_038944283.1  general transcription factor IIE subunit 1 isoform X1

    UniProtKB/TrEMBL
    A6IR94, G3V992
    Conserved Domains (2) summary
    smart00531
    Location:28 → 175
    TFIIE; Transcription initiation factor IIE
    pfam11521
    Location:393 → 438
    TFIIE-A_C; C-terminal general transcription factor TFIIE alpha

  2. XM_017597999.3 → XP_017453488.1  general transcription factor IIE subunit 1 isoform X1

    UniProtKB/TrEMBL
    A6IR94, G3V992
    Conserved Domains (2) summary
    smart00531
    Location:28 → 175
    TFIIE; Transcription initiation factor IIE
    pfam11521
    Location:393 → 438
    TFIIE-A_C; C-terminal general transcription factor TFIIE alpha

  3. XM_039088354.2 → XP_038944282.1  general transcription factor IIE subunit 1 isoform X1

    UniProtKB/TrEMBL
    A6IR94, G3V992
    Conserved Domains (2) summary
    smart00531
    Location:28 → 175
    TFIIE; Transcription initiation factor IIE
    pfam11521
    Location:393 → 438
    TFIIE-A_C; C-terminal general transcription factor TFIIE alpha

  4. XM_008768731.4 → XP_008766953.1  general transcription factor IIE subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_008766953.1

    UniProtKB/TrEMBL
    A6IR94, G3V992
    Conserved Domains (2) summary
    smart00531
    Location:28 → 175
    TFIIE; Transcription initiation factor IIE
    pfam11521
    Location:393 → 438
    TFIIE-A_C; C-terminal general transcription factor TFIIE alpha
Nucleotide Protein Strain
Heading Accession and Version

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