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th tyrosine hydroxylase [ Danio rerio (zebrafish) ]

Gene ID: 30384, updated on 29-Jan-2023

Summary

Official Symbol
thprovided by ZNC
Official Full Name
tyrosine hydroxylaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990621-5
See related
Ensembl:ENSDARG00000030621 AllianceGenome:ZFIN:ZDB-GENE-990621-5
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Enables tyrosine 3-monooxygenase activity. Acts upstream of or within dopamine biosynthetic process and spinal cord motor neuron differentiation. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in axon; cytoplasm; and perikaryon. Is expressed in several structures, including chromaffin cell; digestive system; head; nervous system; and posterior presumptive neural plate. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinsonism; hypertension; and obesity. Orthologous to human TH (tyrosine hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

Location:
chromosome: 25
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (24055341..24074500, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (23957793..23976952, complement)
103 previous assembly Zv9 (GCF_000002035.4) 25 NC_007136.5 (24778680..24797839, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101882916 Neighboring gene insulin-like growth factor 2b Neighboring gene si:dkeyp-19e1.3 Neighboring gene UEV and lactate/malate dehyrogenase domains

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by ZFIN

Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in perikaryon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tyrosine 3-monooxygenase
Names
th1
NP_571224.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131149.1NP_571224.1  tyrosine 3-monooxygenase

    See identical proteins and their annotated locations for NP_571224.1

    Status: PROVISIONAL

    Source sequence(s)
    AL954320
    UniProtKB/TrEMBL
    B3DJW5, B3DJX1, F6NQW5
    Related
    ENSDARP00000040409.6, ENSDART00000040410.7
    Conserved Domains (3) summary
    TIGR01269
    Location:36489
    Tyr_3_monoox; tyrosine 3-monooxygenase, tetrameric
    pfam00351
    Location:157486
    Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
    cl09141
    Location:36151
    ACT; ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    24055341..24074500 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395205.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    525133..544696 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)