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th tyrosine hydroxylase [ Danio rerio (zebrafish) ]

Gene ID: 30384, updated on 14-Jun-2025
Official Symbol
thprovided by ZNC
Official Full Name
tyrosine hydroxylaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990621-5
See related
Ensembl:ENSDARG00000030621 AllianceGenome:ZFIN:ZDB-GENE-990621-5
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Enables tyrosine 3-monooxygenase activity. Acts upstream of or within dopamine biosynthetic process and spinal cord motor neuron differentiation. Predicted to be located in cell projection and perinuclear region of cytoplasm. Predicted to be active in axon; cytoplasm; and perikaryon. Is expressed in several structures, including chromaffin cell; digestive system; head; nervous system; and posterior presumptive neural plate. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinsonism; heroin dependence; hypertension; and obesity. Orthologous to human TH (tyrosine hydroxylase). [provided by Alliance of Genome Resources, Jun 2025]
Orthologs
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Location:
chromosome: 25
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 25 NC_133200.1 (25263583..25282834, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 25 NC_007136.7 (24055341..24074500, complement)

Chromosome 25 - NC_133200.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101882916 Neighboring gene insulin-like growth factor 2b Neighboring gene si:dkeyp-19e1.3 Neighboring gene UEV and lactate/malate dehyrogenase domains

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen IEA
Inferred from Electronic Annotation
more info
 
enables tyrosine 3-monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tyrosine 3-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables tyrosine 3-monooxygenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within aromatic amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within catecholamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within catecholamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cognition IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in dopamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within dopamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dopamine biosynthetic process from tyrosine IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in epinephrine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mating behavior IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in norepinephrine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in serotonin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within spinal cord motor neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic transmission, dopaminergic IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axon IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in perikaryon IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
tyrosine 3-monooxygenase
Names
th1
NP_571224.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131149.1NP_571224.1  tyrosine 3-monooxygenase

    See identical proteins and their annotated locations for NP_571224.1

    Status: PROVISIONAL

    Source sequence(s)
    JBMGRA010000025
    UniProtKB/TrEMBL
    B3DJW5, B3DJX1, F6NQW5
    Related
    ENSDARP00000040409.6, ENSDART00000040410.7
    Conserved Domains (3) summary
    TIGR01269
    Location:36489
    Tyr_3_monoox; tyrosine 3-monooxygenase, tetrameric
    pfam00351
    Location:157486
    Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
    cl09141
    Location:36151
    ACT; ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133200.1 Reference GRCz12tu Primary Assembly

    Range
    25263583..25282834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)