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HAS3 hyaluronan synthase 3 [ Homo sapiens (human) ]

Gene ID: 3038, updated on 23-Nov-2023

Summary

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Official Symbol
HAS3provided by HGNC
Official Full Name
hyaluronan synthase 3provided by HGNC
Primary source
HGNC:HGNC:4820
See related
Ensembl:ENSG00000103044 MIM:602428; AllianceGenome:HGNC:4820
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Expression
Broad expression in urinary bladder (RPKM 19.2), lung (RPKM 12.8) and 24 other tissues See more
Orthologs
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Genomic context

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See HAS3 in Genome Data Viewer
Location:
16q22.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (69083484..69118719)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (74879801..74915029)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (69139556..69152622)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene transport and golgi organization 6 homolog Neighboring gene deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like Neighboring gene ribosomal protein S2 pseudogene 45 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11034 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:69096798-69097616 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:69105561-69106280 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:69106281-69106998 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69106999-69107717 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69107718-69108435 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69111819-69112338 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69122977-69123854 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69131715-69132540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:69133965-69134466 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:69139221-69139769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7651 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69143266-69144235 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7652 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7653 Neighboring gene chromosome transmission fidelity factor 8 Neighboring gene DERPC proline and glycine rich nuclear protein Neighboring gene Sharpr-MPRA regulatory region 12307 Neighboring gene UTP4 small subunit processome component Neighboring gene RNA, U6 small nuclear 22, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. 4-Methylumebelliferone Enhances Radiosensitizing Effects of Radioresistant Oral Squamous Cell Carcinoma Cells via Hyaluronan Synthase 3 Suppression. Hasegawa K, et al. Cells, 2022 Nov 25. PMID 36497040, Free PMC Article
  2. A Connecting Link between Hyaluronan Synthase 3-Mediated Hyaluronan Production and Epidermal Function. Ota Y, et al. Int J Mol Sci, 2022 Feb 22. PMID 35269567, Free PMC Article
  3. Endothelial Hyaluronan Synthase 3 Augments Postischemic Arteriogenesis Through CD44/eNOS Signaling. Schneckmann R, et al. Arterioscler Thromb Vasc Biol, 2021 Oct. PMID 34380333
  4. UDP-sugar substrates of HAS3 regulate its O-GlcNAcylation, intracellular traffic, extracellular shedding and correlate with melanoma progression. Deen AJ, et al. Cell Mol Life Sci, 2016 Aug. PMID 26883802
  5. Hyaluronan synthase 3 (HAS3) overexpression downregulates MV3 melanoma cell proliferation, migration and adhesion. Takabe P, et al. Exp Cell Res, 2015 Sep 10. PMID 26222208

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. 4-Methylumebelliferone Enhances Radiosensitizing Effects of Radioresistant Oral Squamous Cell Carcinoma Cells via Hyaluronan Synthase 3 Suppression.
    Title: 4-Methylumebelliferone Enhances Radiosensitizing Effects of Radioresistant Oral Squamous Cell Carcinoma Cells via Hyaluronan Synthase 3 Suppression.
  2. Hyaluronan synthase 3 is protective after cardiac ischemia-reperfusion by preserving the T cell response.
    Title: Hyaluronan synthase 3 is protective after cardiac ischemia-reperfusion by preserving the T cell response.
  3. A Connecting Link between Hyaluronan Synthase 3-Mediated Hyaluronan Production and Epidermal Function.
    Title: A Connecting Link between Hyaluronan Synthase 3-Mediated Hyaluronan Production and Epidermal Function.
  4. Endothelial Hyaluronan Synthase 3 Augments Postischemic Arteriogenesis Through CD44/eNOS Signaling.
    Title: Endothelial Hyaluronan Synthase 3 Augments Postischemic Arteriogenesis Through CD44/eNOS Signaling.
  5. HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells.
    Title: HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells.
  6. The regulation of HAS3 by miR-10b and miR-29a in neuroendocrine transdifferentiated LNCaP prostate cancer cells.
    Title: The regulation of HAS3 by miR-10b and miR-29a in neuroendocrine transdifferentiated LNCaP prostate cancer cells.
  7. There was a higher HAS1 and HAS2 reactivity and lower HAS3 reactivity in the PCOS endometrium compared to women with regular menstrual cycles in the proliferative phase.
    Title: Analysis of hyaluronic acid in the endometrium of women with polycystic ovary syndrome.
  8. Study shows that HAS3 is induced by IL-1beta in vascular smooth muscle cells and that HAS3 is critically involved in early macrophage driven inflammation.
    Title: Hyaluronan synthase 3 promotes plaque inflammation and atheroprogression.
  9. miR-29a-3p can inhibit gastric cancer cells proliferation and metastasis by regulation HAS3 expression. These findings reveal a new mechanism by which, at least partially, miR-29a-3p may act as a candidate tumor suppressor.
    Title: miR‑29a‑3p represses proliferation and metastasis of gastric cancer cells via attenuating HAS3 levels.
  10. Hyaluronan synthase 3 (HAS3) and tumor necrosis factor-alpha (TNF-alpha) formed an inter-regulation loop to enhance tumorigenesis in oral cancer.
    Title: Hyaluronan synthase 3 mediated oncogenic action through forming inter-regulation loop with tumor necrosis factor alpha in oral cancer.
Submit: New GeneRIF Correction See all GeneRIFs (34)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hyaluronan synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hyaluronan synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hyaluronan synthase activity TAS
Traceable Author Statement
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in extracellular matrix assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in extracellular matrix assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in extracellular polysaccharide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in extracellular polysaccharide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in hyaluronan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hyaluronan biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in hyaluronan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in hyaluronan biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of hyaluranon cable assembly IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in hyaluranon cable IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
hyaluronan synthase 3
Names
HA synthase 3
hyaluronate synthase 3
hyaluronic acid synthase 3
NP_001186209.1
NP_005320.2
NP_619515.1
XP_005255978.1
XP_011521363.1
XP_047290001.1
XP_047290002.1
XP_047290003.1
XP_054236175.1
XP_054236176.1
XP_054236177.1
XP_054236178.1
XP_054236179.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047056.2 RefSeqGene

    Range
    27171..39178
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001199280.2 → NP_001186209.1  hyaluronan synthase 3 isoform a

    See identical proteins and their annotated locations for NP_001186209.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Both variants 1 and 3 encode the same protein (isoform a).
    Source sequence(s)
    AC009027, AK291400
    Consensus CDS
    CCDS10871.1
    UniProtKB/Swiss-Prot
    A8K5T5, O00219, Q8WTZ0, Q9NYP0
    UniProtKB/TrEMBL
    Q96RV2
    Related
    ENSP00000454731.1, ENST00000569188.6
    Conserved Domains (1) summary
    cd06434
    Location:86 → 364
    GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan

  2. NM_005329.3 → NP_005320.2  hyaluronan synthase 3 isoform a

    See identical proteins and their annotated locations for NP_005320.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) contains a different 5' exon as compared to variant 3. Both variants 1 and 3 encode the same protein (isoform a).
    Source sequence(s)
    AC009027, AF234839
    Consensus CDS
    CCDS10871.1
    UniProtKB/Swiss-Prot
    A8K5T5, O00219, Q8WTZ0, Q9NYP0
    UniProtKB/TrEMBL
    Q96RV2
    Related
    ENSP00000304440.1, ENST00000306560.1
    Conserved Domains (1) summary
    cd06434
    Location:86 → 364
    GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan

  3. NM_138612.3 → NP_619515.1  hyaluronan synthase 3 isoform b

    See identical proteins and their annotated locations for NP_619515.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a different 5' and 3' exon as compared to variant 3. As a result, variant 2 encodes isoform b, which has the same N-terminus but is shorter and has a different C-terminus than isoform a encoded by variant 3.
    Source sequence(s)
    AC009027, BC021853
    Consensus CDS
    CCDS10870.1
    UniProtKB/TrEMBL
    H3BRH5
    Related
    ENSP00000219322.3, ENST00000219322.7
    Conserved Domains (1) summary
    cl11394
    Location:86 → 247
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    69083484..69118719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434047.1 → XP_047290003.1  hyaluronan synthase 3 isoform X1

    UniProtKB/Swiss-Prot
    A8K5T5, O00219, Q8WTZ0, Q9NYP0
    UniProtKB/TrEMBL
    Q96RV2

  2. XM_047434046.1 → XP_047290002.1  hyaluronan synthase 3 isoform X1

    UniProtKB/Swiss-Prot
    A8K5T5, O00219, Q8WTZ0, Q9NYP0
    UniProtKB/TrEMBL
    Q96RV2

  3. XM_047434045.1 → XP_047290001.1  hyaluronan synthase 3 isoform X1

    UniProtKB/Swiss-Prot
    A8K5T5, O00219, Q8WTZ0, Q9NYP0
    UniProtKB/TrEMBL
    Q96RV2

  4. XM_011523061.3 → XP_011521363.1  hyaluronan synthase 3 isoform X1

    See identical proteins and their annotated locations for XP_011521363.1

    UniProtKB/Swiss-Prot
    A8K5T5, O00219, Q8WTZ0, Q9NYP0
    UniProtKB/TrEMBL
    Q96RV2
    Conserved Domains (1) summary
    cd06434
    Location:86 → 364
    GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan

  5. XM_005255921.3 → XP_005255978.1  hyaluronan synthase 3 isoform X1

    See identical proteins and their annotated locations for XP_005255978.1

    UniProtKB/Swiss-Prot
    A8K5T5, O00219, Q8WTZ0, Q9NYP0
    UniProtKB/TrEMBL
    Q96RV2
    Conserved Domains (1) summary
    cd06434
    Location:86 → 364
    GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    74879801..74915029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054380204.1 → XP_054236179.1  hyaluronan synthase 3 isoform X1

    UniProtKB/Swiss-Prot
    A8K5T5, O00219, Q8WTZ0, Q9NYP0
    UniProtKB/TrEMBL
    Q96RV2

  2. XM_054380203.1 → XP_054236178.1  hyaluronan synthase 3 isoform X1

    UniProtKB/Swiss-Prot
    A8K5T5, O00219, Q8WTZ0, Q9NYP0
    UniProtKB/TrEMBL
    Q96RV2

  3. XM_054380202.1 → XP_054236177.1  hyaluronan synthase 3 isoform X1

    UniProtKB/Swiss-Prot
    A8K5T5, O00219, Q8WTZ0, Q9NYP0
    UniProtKB/TrEMBL
    Q96RV2

  4. XM_054380200.1 → XP_054236175.1  hyaluronan synthase 3 isoform X1

    UniProtKB/Swiss-Prot
    A8K5T5, O00219, Q8WTZ0, Q9NYP0
    UniProtKB/TrEMBL
    Q96RV2

  5. XM_054380201.1 → XP_054236176.1  hyaluronan synthase 3 isoform X1

    UniProtKB/Swiss-Prot
    A8K5T5, O00219, Q8WTZ0, Q9NYP0
    UniProtKB/TrEMBL
    Q96RV2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O00219.3 GenPept UniProtKB/Swiss-Prot:O00219

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