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Notum NOTUM, palmitoleoyl-protein carboxylesterase [ Rattus norvegicus (Norway rat) ]

Gene ID: 303743, updated on 13-Aug-2019

Summary

Official Symbol
Notumprovided by RGD
Official Full Name
NOTUM, palmitoleoyl-protein carboxylesteraseprovided by RGD
Primary source
RGD:1307119
See related
Ensembl:ENSRNOG00000036680
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307119
Expression
Biased expression in Liver (RPKM 96.2), Thymus (RPKM 23.3) and 3 other tissues See more
Orthologs

Genomic context

See Notum in Genome Data Viewer
Location:
10q32.3
Exon count:
13
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109832977..109840661, complement)
106 current Rn_Celera (GCF_000002265.2) 10 AC_000078.1 (104476752..104483846, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (109425669..109432739, complement)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene MAF bZIP transcription factor G Neighboring gene pyrroline-5-carboxylate reductase 1 Neighboring gene myeloid-associated differentiation marker-like 2 Neighboring gene ASPSCR1 tether for SLC2A4, UBX domain containing Neighboring gene centromere protein X

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

  • Wnt signaling pathway, organism-specific biosystem (from KEGG)
    Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt signaling pathway, conserved biosystem (from KEGG)
    Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

General gene information

Homology

Clone Names

  • MGC109547

Gene Ontology Provided by RGD

Function Evidence Code Pubs
palmitoleyl hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
palmitoleyl hydrolase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
NOT GPI anchor release ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein depalmitoleylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein depalmitoleylation ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
palmitoleoyl-protein carboxylesterase NOTUM
NP_001013997.2
XP_006247949.1
XP_006247950.1
XP_017452837.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013975.2NP_001013997.2  palmitoleoyl-protein carboxylesterase NOTUM precursor

    Status: VALIDATED

    Source sequence(s)
    BQ204914, CB768482, CO562343, DV215880, EX493402
    UniProtKB/TrEMBL
    D3ZXI3
    Related
    ENSRNOP00000051830.2, ENSRNOT00000054947.2
    Conserved Domains (1) summary
    pfam03283
    Location:89424
    PAE; Pectinacetylesterase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    109832977..109840661 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597348.1XP_017452837.1  palmitoleoyl-protein carboxylesterase NOTUM isoform X2

    UniProtKB/TrEMBL
    D3ZXI3
    Conserved Domains (1) summary
    pfam03283
    Location:89424
    PAE; Pectinacetylesterase
  2. XM_006247887.3XP_006247949.1  palmitoleoyl-protein carboxylesterase NOTUM isoform X1

    See identical proteins and their annotated locations for XP_006247949.1

    Conserved Domains (1) summary
    pfam03283
    Location:124459
    PAE; Pectinacetylesterase
  3. XM_006247888.3XP_006247950.1  palmitoleoyl-protein carboxylesterase NOTUM isoform X3

    Conserved Domains (1) summary
    pfam03283
    Location:50358
    PAE; Pectinacetylesterase

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    104476752..104483846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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