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Arsg arylsulfatase G [ Rattus norvegicus (Norway rat) ]

Gene ID: 303631, updated on 8-Apr-2026
Official Symbol
Arsgprovided by RGD
Official Full Name
arylsulfatase Gprovided by RGD
Primary source
RGD:1306571
See related
Ensembl:ENSRNOG00000003931 AllianceGenome:RGD:1306571
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306571
Summary
Predicted to enable N-sulfoglucosamine-3-sulfatase activity and arylsulfatase activity. Predicted to be involved in sulfur compound metabolic process. Predicted to act upstream of or within several processes, including lysosome organization; neuron apoptotic process; and retina development in camera-type eye. Predicted to be located in endoplasmic reticulum; extracellular space; and lysosome. Human ortholog(s) of this gene implicated in Usher syndrome. Orthologous to human ARSG (arylsulfatase G). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Adrenal (RPKM 49.0), Spleen (RPKM 37.0) and 9 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Arsg in Genome Data Viewer
Location:
10q32.1
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (94912094..95063021)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (94412261..94551224)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (97722550..97859975)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene G protein subunit alpha 13 Neighboring gene archaelysin family metallopeptidase 2 Neighboring gene 5E5 antigen-like Neighboring gene solute carrier family 16, member 6 Neighboring gene WD repeat domain, phosphoinositide interacting 1 Neighboring gene uncharacterized LOC100912202 Neighboring gene protein kinase cAMP-dependent type I regulatory subunit alpha Neighboring gene uncharacterized LOC134480894 Neighboring gene FAM20A, golgi associated secretory pathway pseudokinase

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Arylsulfatase G, a novel lysosomal sulfatase. Frese MA, et al. J Biol Chem, 2008 Apr 25. PMID 18283100
  2. Molecular and biochemical characterisation of a novel sulphatase gene: Arylsulfatase G (ARSG). Ferrante P, et al. Eur J Hum Genet, 2002 Dec. PMID 12461688
  3. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. Sardiello M, et al. Hum Mol Genet, 2005 Nov 1. PMID 16174644
  4. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N-sulfoglucosamine-3-sulfatase activity IEA
Inferred from Electronic Annotation
more info
  
enables N-sulfoglucosamine-3-sulfatase activity ISO
Inferred from Sequence Orthology
more info
  
enables arylsulfatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables arylsulfatase activity ISO
Inferred from Sequence Orthology
more info
  
enables arylsulfatase activity ISO
Inferred from Sequence Orthology
more info
  
enables arylsulfatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within homeostasis of number of cells ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lysosome organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within retina development in camera-type eye ISO
Inferred from Sequence Orthology
more info
  
involved_in sulfur compound metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
arylsulfatase G
Names
ASG
N-sulfoglucosamine-3-sulfatase
NP_001041342.1
XP_006247664.1
XP_006247666.1
XP_006247668.1
XP_006247669.1
XP_006247670.1
XP_008766591.1
XP_038942102.1
XP_038942103.1
XP_038942104.1
XP_038942105.1
XP_063125292.1
XP_063125293.1
XP_063125294.1
XP_063125295.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001047877.2 → NP_001041342.1  arylsulfatase G precursor

    See identical proteins and their annotated locations for NP_001041342.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q32KJ9
    UniProtKB/TrEMBL
    A6HKB4
    Conserved Domains (1) summary
    cd16161
    Location:35 → 469
    ARSG; arylsulfatase G

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    94912094..95063021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269225.1 → XP_063125295.1  arylsulfatase G isoform X2

  2. XM_039086177.2 → XP_038942105.1  arylsulfatase G isoform X4

    Conserved Domains (1) summary
    cl23718
    Location:35 → 328
    ALP_like; alkaline phosphatases and sulfatases

  3. XM_039086176.2 → XP_038942104.1  arylsulfatase G isoform X3

    Conserved Domains (1) summary
    cl23718
    Location:35 → 331
    ALP_like; alkaline phosphatases and sulfatases

  4. XM_008768369.3 → XP_008766591.1  arylsulfatase G isoform X1

    See identical proteins and their annotated locations for XP_008766591.1

    UniProtKB/Swiss-Prot
    Q32KJ9
    UniProtKB/TrEMBL
    A6HKB4
    Conserved Domains (1) summary
    cd16161
    Location:35 → 469
    ARSG; arylsulfatase G

  5. XM_039086174.2 → XP_038942102.1  arylsulfatase G isoform X1

    UniProtKB/Swiss-Prot
    Q32KJ9
    UniProtKB/TrEMBL
    A6HKB4
    Related
    ENSRNOP00000086727.1, ENSRNOT00000113597.2
    Conserved Domains (1) summary
    cd16161
    Location:35 → 469
    ARSG; arylsulfatase G

  6. XM_039086175.2 → XP_038942103.1  arylsulfatase G isoform X1

    UniProtKB/Swiss-Prot
    Q32KJ9
    UniProtKB/TrEMBL
    A6HKB4
    Conserved Domains (1) summary
    cd16161
    Location:35 → 469
    ARSG; arylsulfatase G

  7. XM_006247602.5 → XP_006247664.1  arylsulfatase G isoform X1

    See identical proteins and their annotated locations for XP_006247664.1

    UniProtKB/Swiss-Prot
    Q32KJ9
    UniProtKB/TrEMBL
    A6HKB4
    Conserved Domains (1) summary
    cd16161
    Location:35 → 469
    ARSG; arylsulfatase G

  8. XM_006247608.5 → XP_006247670.1  arylsulfatase G isoform X1

    See identical proteins and their annotated locations for XP_006247670.1

    UniProtKB/Swiss-Prot
    Q32KJ9
    UniProtKB/TrEMBL
    A6HKB4
    Conserved Domains (1) summary
    cd16161
    Location:35 → 469
    ARSG; arylsulfatase G

  9. XM_063269222.1 → XP_063125292.1  arylsulfatase G isoform X1

    UniProtKB/Swiss-Prot
    Q32KJ9
    UniProtKB/TrEMBL
    A6HKB4

  10. XM_006247604.5 → XP_006247666.1  arylsulfatase G isoform X1

    See identical proteins and their annotated locations for XP_006247666.1

    UniProtKB/Swiss-Prot
    Q32KJ9
    UniProtKB/TrEMBL
    A6HKB4
    Conserved Domains (1) summary
    cd16161
    Location:35 → 469
    ARSG; arylsulfatase G

  11. XM_006247606.5 → XP_006247668.1  arylsulfatase G isoform X1

    See identical proteins and their annotated locations for XP_006247668.1

    UniProtKB/Swiss-Prot
    Q32KJ9
    UniProtKB/TrEMBL
    A6HKB4
    Conserved Domains (1) summary
    cd16161
    Location:35 → 469
    ARSG; arylsulfatase G

  12. XM_063269223.1 → XP_063125293.1  arylsulfatase G isoform X1

    UniProtKB/Swiss-Prot
    Q32KJ9
    UniProtKB/TrEMBL
    A6HKB4

  13. XM_063269224.1 → XP_063125294.1  arylsulfatase G isoform X1

    UniProtKB/Swiss-Prot
    Q32KJ9
    UniProtKB/TrEMBL
    A6HKB4

  14. XM_006247607.5 → XP_006247669.1  arylsulfatase G isoform X1

    See identical proteins and their annotated locations for XP_006247669.1

    UniProtKB/Swiss-Prot
    Q32KJ9
    UniProtKB/TrEMBL
    A6HKB4
    Conserved Domains (1) summary
    cd16161
    Location:35 → 469
    ARSG; arylsulfatase G

RNA

  1. XR_005489859.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q32KJ9.1 GenPept UniProtKB/Swiss-Prot:Q32KJ9

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