hoxb8a homeobox B8a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hoxb8aprovided by ZNC
Official Full Name: homeobox B8aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-108
See related: Ensembl:ENSDARG00000056027 AllianceGenome:ZFIN:ZDB-GENE-990415-108
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gp-8; hoxb8; fj67g02; zgc:64159; wu:fj67g02
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within cell population proliferation and posterior lateral line neuromast primordium migration. Predicted to be active in nucleus. Is expressed in several structures, including nervous system; neural tube; pancreatic system; paraxial mesoderm; and pronephros. Orthologous to human HOXB8 (homeobox B8). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	3	NC_133178.1 (22427829..22430587)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (23687897..23690481)

Chromosome 3 - NC_133178.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hoxb8a is induced by and cooperates with Wnt signaling to up-regulate cxcr4b, and acts through multiple mechanisms to repress cxcr7b expression.
Title: A Hox gene controls lateral line cell migration by regulating chemokine receptor expression downstream of Wnt signaling.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within posterior lateral line neuromast primordium migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein Hox-B8a

Names: homeo box B8a; homeobox gene B-8; hox-B8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131120.1 → NP_571195.1 homeobox protein Hox-B8a

See identical proteins and their annotated locations for NP_571195.1

Status: PROVISIONAL

Source sequence(s)

BC053287

UniProtKB/Swiss-Prot

O57363, Q4PRA0, Q8AWZ0

Related

ENSDARP00000046637.7, ENSDART00000046638.8

Conserved Domains (1) summary

pfam00046
Location:149 → 201

Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

NC_133178.1 Reference GRCz12tu Primary Assembly

Range

22427829..22430587

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005171563.6 → XP_005171620.1 homeobox protein Hox-B8a isoform X1

UniProtKB/TrEMBL

A0A8M2BJC8

Conserved Domains (1) summary

pfam00046
Location:150 → 202

Homeobox; Homeobox domain